口服普萘洛尔治疗婴儿眼睑血管瘤的疗效观察  

Effects of oral propranolol for infantile eyelid periorbital hemangioma

作　　者：韦美荣 田桂芬[2] 

机构地区：[1]广西柳州市妇幼保健院眼科,545001 [2]北京大学第一医院小儿眼科

出　　处：《中国斜视与小儿眼科杂志》2015年第4期28-31,共4页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的观察普萘洛尔治疗婴儿眼睑血管瘤的效果。方法对13例眼睑血管瘤婴儿采用普萘洛尔口服治疗,并于给药后第24小时、第1周、第2周、第1个月、第3个月、第6个月及第8个月随访观察瘤体颜色及大小的变化。结果 13例眼睑血管瘤婴儿服药1周内颜色变浅,给药后1周总有效率100%;1月后瘤体范围不同程度缩小;6个月后血管瘤完全消退10例,8个月后13例完全消退;停药后1月随访,有1例复发(9%),继续给药1月后瘤体完全消退,逐渐减量直至停药,随访半年至今未见再发,未见严重不良反应发生,消退率100%,8个月完全治愈率91%。结论口服普萘洛尔治疗婴儿眼睑血管瘤安全且疗效好,值得在临床推广应用。Objective To explore the effect of oral propranolol for children eyelid periorbital hemangioma.Methods 13 infants（21 eyes） with eyelid periorbital hemangioma were treated with oral propranolol according to prescribed medication. Hemangioma height and color changed were observed at 24 hours, 1 week, 2 weeks, 1months, 3 months, 6 months and 8 months after receiving propranolol respectively. To evaluate safety of the treatment, all infants were followed up to 6 months after drug withdrawal. Results Hemangioma color of all cases became lighter within 1 week after the medications. The effective rate of treatment was 100%. The tumors present different diminution after the first 4 weeks. Tumors of 10 cases were disappeared after 6 months. All cases were cured after 8 months. One case（9%） recurred after drug withdrawal and completely regressive with treatment continuously for a month. Follow-up for half a year, no recurrence and adverse reactions were observed in all participants. The regressive rate and cure rate of treatment was 100%. Conclusion Oral propranolol is safe and has significant therapeutic effects on eyelid periorbital hemangioma, and worthy to be popularized.

关 键 词：婴幼儿 眼睑血管瘤 普萘洛尔 

分 类 号：R739.71[医药卫生—肿瘤]