HBV相关的慢性肝病与胰岛素抵抗的研究进展  

HBV-related chronic liver disease and insulin resistance

作　　者：黄亚雄[1] 谢元林[1] 

机构地区：[1]南华大学附属长沙医院感染科,湖南省长沙市410000

出　　处：《世界华人消化杂志》2015年第36期5803-5808,共6页World Chinese Journal of Digestology

摘　　要：肝脏是调节血糖代谢的重要脏器,肝细胞受损时可能出现糖代谢紊乱及胰岛素抵抗(insulin resistance,IR),甚至发展为肝源性糖尿病.目前病毒性肝炎、肝硬化与糖尿病的相关性研究已经成为近年来的热点问题,本文就乙型肝炎病毒(hepatitis B virus,HBV)感染与糖尿病的早期预测指标的研究新进展作一综述,简单介绍了IR的概念及出现的原因,详细阐述了HBV感染、HBV及丙型肝炎病毒重叠感染、肝炎肝硬化与IR的相互联系,并附带介绍了乙型肝炎病毒感染人群出现IR的有关机制.关于IR对HBV相关的慢性肝病患者预后的影响,本文主要阐述的是IR对HBV感染人群出现脂肪肝、肝纤维化、肝癌的影响,该综述还明确讲述了HBV感染并IR人群的临床治疗.The liver is the major organ regulating glucose metabolism. When liver injury occurs, glucose metabolism disturbance and insulin resistance （IR） may develop, which can even cause the development of hepatogenic diabetes. The correlation between viral hepatitis, liver cirrhosisand diabetes has become a hot research topic in recent years. This paper reviews the progress in research of hepatitis B virus （HBV） infection and early predictors of diabetes. We give a brief introduction to the concept of IR and its causes, and discuss the relationship of HBV infection, HBV and HCV coinfection, and hepatitis associated cirrhosis with IR. We also describe the possible mechanisms for IR in HBV infected people. Besides, we discuss the impact of IR on prognosis of HBV related chronic liver diseases, mainly fatty, liver fibrosis, and liver cancer. The clinical treatment of patients with HBV infection and IR is also discussed.

关 键 词：乙型肝炎病毒 胰岛素抵抗 非酒精性脂肪肝病 肝癌 

分 类 号：R575[医药卫生—消化系统]