血小板计数与凝血功能指标对乙型肝炎肝硬化患者的临床意义  

Clinical significance of platelet count and coagulation function indexes in patients with hepatitis B and liver cirrhosis

作　　者：汤磊[1] 彭蕾[1] 郜玉峰[1] 叶珺[1] 邹桂舟[1] 

机构地区：[1]安徽医科大学第二附属医院肝病科,合肥230601

出　　处：《中国肝脏病杂志（电子版）》2015年第4期101-103,共3页Chinese Journal of Liver Diseases：Electronic Version

基　　金：安徽医科大学校科学研究基金资助项目(2015xkj029)

摘　　要：目的分析血小板计数和凝血功能指标对乙型肝炎肝硬化患者的临床意义。方法分别采用全自动血液分析仪和全自动血凝仪检测112例肝硬化患者和78例健康对照者的血小板计数(PLT)和凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)并进行分析;进一步研究肝硬化患者中38例消化道出血者与74例无出血者以上指标的差异。结果与78例健康对照组比较,112例乙型肝炎肝硬化组患者PLT显著下降(P=0.0062),而PT、APTT显著延长(P=0093、P=0.0088);肝硬化出血组与未出血组患者的PLT、PT、APTT也存在显著差异(P=0.0098、P=0.048、P=0.016)。结论血小板计数和凝血功能指标对肝硬化患者出血倾向和预后判断具有重要意义。Objective To investigate the clinical significance of platelet count and coagulation function indexes in patients with hepatitis B cirrhosis. Methods The platelet parameters（PLT） and the coagulation indexes（PT, APTT） of 112 patients with liver cirrhosis and 78 healthy people were detected by auto-counter and auto-blood coagulation analyzer respectively, and the results were compared. The differences of those indicators between the 38 cases of liver cirrhosis bleeding and the 74 cases without bleeding were analyzed furtherly. Results Compared with 78 cases of healthy control group, PLT of 112 patients in liver cirrhosis group decreased evidently; PT and APTT in these patients were longer than those in the control group, with significant differences between the two groups（P = 0.0062, P = 0.0093 and P = 0.0088）. There were also significant differences in PLT, PT and APTT in the cases of liver cirrhosis bleeding and without bleeding（P = 0.0098、P = 0.048 and P = 0.016）. Conclusion The platelet count and coagulation indexes can be used as important indexes to determine the damage degree and the prognosis of hepatic B and liver cirrhosis patients.

关 键 词：血小板计数 凝血指标 乙型肝炎肝硬化 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]