左卡尼汀对腹膜透析患者营养及微炎症状态的影响  

Influence of levocarnitine on nutritional and microinflammatory state in peritoneal dialysis patients

作　　者：高峰[1] 李芳[1] 贺晓[1] 

机构地区：[1]武警辽宁总队大连医院肾内科,辽宁大连116013

出　　处：《临床军医杂志》2015年第5期472-474,共3页Clinical Journal of Medical Officers

摘　　要：目的观察左卡尼汀对持续性非卧床式腹膜透析(CAPD)患者营养状况及微炎症状态的影响。方法将68例CAPD患者随机分为左卡尼汀治疗组和对照组,分别在两组治疗前、治疗3个月后送检超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、一氧化氮(NO)、血红蛋白(Hb)、白蛋白(Alb)、转铁蛋白(TF)、胆固醇(Chol),观察CAPD患者各生化指标的变化。结果治疗组34例CAPD患者服用左卡尼汀治疗3个月后,Hb、TF、Alb、hs-CRP、IL-6、NO水平与治疗前比较差异有统计学意义(P<0.05),与对照组比较差异也有统计学意义(P<0.05);血清Chol水平与治疗前及与对照组比较差异无统计学意义(P>0.05)。结论左卡尼汀对CAPD患者的营养不良及微炎症状态具有治疗作用。Objective To investigate into the effect of levocarnitine on nutritional and microinflammatory state in peritoneal dialysis patients. Methods Sixty-eight peritoneal dialysis patients were divided in trial group treated with levocarnitine（ 1 g,twice per day for 3 months） and control group. Serum hypersensitive C-reactive protein（ hs-CRP）,interleukin-6（ IL-6）,nitricoxide（ NO）,hemoglobin（ Hb）,albumin（ ALB）,cholesterol（ Chol） and transferrin（ TF） were measured before and after three months＇ treatment of levocarnitine. Results The levels of Hb,TF,Alb,hs-CRP,IL-6 and NO of the trial group after three months＇ treatment were significantly different from before（ P〈0. 05） and from that of the control group after treatment（ P〈0. 05）,except that of cholesterol（ P〉0. 05）. Conclusion Levocarnitine helps to improve the nutritional and microinflammatory state in peritoneal dialysis patients.

关 键 词：左卡尼汀 腹膜透析 营养 微炎症 

分 类 号：R692.5[医药卫生—泌尿科学]