硼替佐米为主的化疗方案和传统化疗方案治疗多发性骨髓瘤的疗效比较  

Comparation of bortezomib based chemotherapy and traditional chemotherapy for untreated multiple myeloma

作　　者：刘湲[1] 陈丽梅[1] 

机构地区：[1]西安交通大学第一附属医院血液科,陕西西安7100611

出　　处：《延安大学学报（医学科学版）》2015年第4期18-20,共3页Journal of Yan'an University:Medical Science Edition

摘　　要：目的比较硼替佐米为主的化疗方案和传统化疗方案治疗初治多发性骨髓瘤（MM）的疗效。方法选取自2009-05-2014-11在榆林市第一医院血液科住院治疗的共36例MM患者,随机分成2组,18例使用硼替佐米联合化疗,18例使用传统的化疗方案,采用国际骨髓瘤工作组（IMWG）的疗效标准判定疗效。比较两组间的疗效,同时对患者的血红蛋白、肌酐,免疫球蛋白等因素行统计学分析。结果两组组间基线比较,性别、年龄、分型、血清学指标、分期间差异,结果无统计学差异（P〉0.05）。硼替佐米组中反应良好率为77.82%,非硼替佐米组反应良好率为44.45%,两组间差异具有统计学意义（P〈0.05）。结论治疗两个疗程后硼替佐米治疗组的疗效优于非硼替佐米治疗组。Objective Tocompare the efficacy of bortezomibbased chemotherapy andtraditional chemotherapy for untreated multiple myeloma（ MM）. Methods Theclinical data of patients admitted to YULIN NO. 1 Hospital from May2009 to November 2014 were retrospectively analyzedafter blood biochemical examination,bone marrow cytology,immunofixation electrophoresis and imaging check. 36 untreated patients with confimed MM were randmoly divided into 2 groups： 18 patients were treated withbortezomib based chemotherapy; 18 cases of control group were treated with traditionalchemotherapy. The clinical characteristics of MM patients＇ gender,ages,typingwas observed and compared the effectiveness of two chemotherapy regiments. Results The comparison of baseline,gentle,age,serological indicator,difference between Durie- Salmon stage between two groups showed that there was no significant statistical difference（ P〉0. 05）. The good response rate for the bortezomib group was 77. 82%,while the control group was 44. 45%,the difference between the two groups have statistical significance（ P〈0. 05）. Conclusion Bortezomib based chemotherapy was more effective than traditional chemotherapy withhigher disease control rate,which can be preferable choice for the treatment of MM.

关 键 词：多发性骨髓瘤 硼替佐米 疗效 

分 类 号：R733.3[医药卫生—肿瘤]