眼内及眼附属器淋巴瘤的组织病理学表现  

Histopathology of ocular and adnexal lymphoma

作　　者：刘忆南 魏文斌[1] 

机构地区：[1]首都医科大学附属北京同仁医院 北京同仁眼科中心 眼科学与视觉科学北京市重点实验室,100730

出　　处：《国际眼科纵览》2015年第6期418-422,共5页International Review of Ophthalmology

基　　金：北京市自然科学基金（7112031）;国家自然科学基金（81272981）;北京市卫生系统高层次卫生技术人才培养计划（2009-3-32）

摘　　要：眼内及眼附属器（眼眶、眼睑、结膜、泪腺、泪囊）淋巴瘤是一种相对少见的眼部恶性肿瘤,近年来全球范围内的发病率有逐渐增高趋势.它们多属于非何杰金淋巴瘤,其中最常见的亚型为高度恶性的弥漫大B细胞淋巴瘤和低度恶性的结外边缘区B细胞淋巴瘤.多数眼内及眼附属器淋巴瘤以B细胞来源为主,免疫组化常可发现B细胞标志物（CD79a、CD20、PAX5）阳性.Ki-67染色显示肿瘤细胞生长因子含量,借以评价淋巴瘤的恶性程度.Ocular and adnexal （including the orbit, eyelid, conjunctiva, lacrimal gland and lacrimal sac） lymphoma is a relatively rare ocular malignant tumor, of which the incidence worldwide tends to be gradually increasing lately.They are the classification of non-Hodgkin＆#39;s lymphoma at most times.And the most common subtype of ocular and adnexal lymphoma are the highly malignant diffuse large B cell lymphoma and low-grade malignant extranodal marginal zone B cell lymphoma.Most of the ocular and adnexal lymphoma cells are derived from B lymphocytes.Immunohistochemistry often shows that B cell markers （CD79a,CD20, PAXS） are positive.Ki-67 staining is used to test tumor cell growth factor levels, so as to evaluate the malignant degree of lymphoma.

关 键 词：眼内淋巴瘤 眼附属器淋巴瘤 组织病理学 免疫组化 

分 类 号：R739.7[医药卫生—肿瘤]