鼻咽癌转移机制与LMP-1关联性的光学表征  

Optical Characteristics of Correlation Between LMP-1 and Metastatic Mechanism of Nasopharyngeal Cancer

作　　者：叶青[1] 孙真臻 张先增[2] 林隽[1] 黄正[2] 谢树森[2] 

机构地区：[1]福建省立医院耳鼻咽喉科,福州市350001 [2]福建师范大学医学光电科学与技术教育部重点实验室

出　　处：《中国激光医学杂志》2015年第6期320-326,共7页Chinese Journal of Laser Medicine & Surgery

基　　金：国家自然科学基金(61475036;81471703)

摘　　要：中国的东南部是全球鼻咽癌高发区域之一,对鼻咽癌转移机制的研究存在强烈的需求。凭借可视化光子技术研究鼻咽癌转移机制与LMP-1癌蛋白的关联性,探索早期预测癌转移的潜在可能并进行调控干预,提高患者的生存率,具有医学理论意义和临床应用价值。本文综述了近年来相关研究的发展趋势,特别是高分辨光学成像技术与荧光相关光谱技术的新进展。展望了以鼻咽癌细胞调控的LMP-1为特异性靶标,结合高灵敏度分子荧光探针技术,获取癌细胞脂筏微区的高分辨光学成像和LMP-1动态聚集特性的光学表征,达到可视化且半定量地预测鼻咽癌转移的倾向,为有效地提高鼻咽癌患者治愈率提供新思路和理论支持。Southeastern China is one of the high prevalence areas for nasopharyngeal cancer （NPC） in the world. There is a strong need to investigate the mechanism of NPC metastasis. It has theoretic importance in medicine and great value in clinical application to explore the correlation between LMP-1 cancer protein and metastatic mechanism by utilizing optical visualization techniques for the early prediction of risk of metastasis, possible preventive intervention and improvement in survival rate. This review summarizes recent research de- velopment and trend in applying high resolution optical imaging and fluorescence correlation spectroscopy technology, including study on specific target of the LMP-1 protein. In combination with high sensitivity fluorescent probes, high resolution optical imaging of lipid rafts can be obtained for the optical characterization of dynamic aggregation properties of LMP-1 in lipid rafts, which can be used for the visualization and semi-quantified prediction of the trend of metastasis. It may provide a new direction and theoretic support for a signifi-cant improvement of the cure rate in NPC treatment.

关 键 词：鼻咽癌 转移 LMP-1 高分辨成像 荧光探针 

分 类 号：R739.63[医药卫生—肿瘤]