Toll样受体1基因多态性与胃癌癌前病变的相关性研究  

Relationship of Toll-like Receptor 1 Gene Polymorphism with Gastric Precancerous Lesions

作　　者：李静[1] 王晓燕[2] 崔艳欣[1] 姜相君[1] 

机构地区：[1]青岛大学医学院附属青岛市市立医院消化内二科,266000 [2]青岛大学医学院附属青岛市市立医院国际门诊,266000

出　　处：《胃肠病学》2015年第12期728-731,共4页Chinese Journal of Gastroenterology

摘　　要：背景：大量研究表明,肠化生、异型增生为胃癌的癌前病变。Toll样受体1（TLR1）基因多态性与多种疾病的发生相关,但与胃癌癌前病变关系的研究少见。目的：探讨TLR1基因rs4833095位点多态性与胃癌癌前病变的相关性。方法：选取2008年12月—2014年12月青岛市市立医院432例胃癌癌前病变患者（包括上皮内瘤变84例、肠化生348例）,同时以540名健康志愿者作为对照。采用DNA测序法检测TLR1基因rs4833095位点基因型,评估幽门螺杆菌（Hp）感染状态。以多因素Logistic回归模型分析TLR1基因多态性与胃癌癌前病变的关系。结果：病例组TLR1基因rs4833095位点GG、GA、AA基因型频率与对照组相比差异有统计学意义（χ^2=19.966,P=0.000）,病例组AA基因型频率明显高于对照组（17.6%对8.9%;χ^2=16.336,P=0.000）。多因素Logistic回归分析显示,与GG基因型相比,携带AA基因型者胃癌癌前病变的发病风险明显增加（OR=1.329,95%CI：1.002-1.762）。与GG＋GA基因型且未感染Hp的患者相比,携带AA基因型并感染Hp者发生胃癌癌前病变的风险明显增加（OR=3.617,95%CI：2.147-6.092）。结论：TLR1 rs4833095基因多态性与胃癌癌前病变发病风险呈正相关。Background： Intestinal metaplasia and intraepithelial neoplasia are precancerous lesions of gastric cancer. Toll-like receptor 1（ TLR1） gene polymorphism is related with many diseases,however,only few studies have been performed on its relationship with gastric precancerous lesions. Aims： To investigate the relationship between TLR1 rs4833095 polymorphism and gastric precancerous lesions. Methods： A total of 432 patients with gastric precancerous lesions（ including 84 intraepithelial neoplasia,348 intestinal metaplasia） from Dec. 2008 to Dec. 2014 at Qingdao Municipal Hospital were enrolled,and 540 healthy subjects were served as controls. TLR1 rs4833095 polymorphism was determined by DNA sequencing,and Helicobacter pylori（ Hp） infection was detected. Relationship of TLR1 gene polymorphism with gastric precancerous lesions was analyzed by multiple Logistic regression model. Results： Significant differences in the frequencies of GG,GA and AA genotype on TLR1 rs4833095 were found between disease group and control group（ χ^2=19. 966,P = 0. 000）. The frequency of AA genotype in disease group was significant higher than that in control group（ 17. 6% vs. 8. 9%; χ^2= 16. 336,P = 0. 000）. Compared with GG genotype,patients with AA genotype were obviously more susceptible to gastric precancerous lesions（ OR = 1. 329,95% CI： 1. 002-1. 762）. Compared with GG ＋ GA genotypes with negative Hp,patients with AA genotype and positive Hp infection had much higher susceptibility to gastric precancerous lesions（ OR = 3. 617,95% CI： 2. 147-6. 092）. Conclusions： TLR1 rs4833095 polymorphism is positively associated with susceptibility to gastric precancerous lesions.

关 键 词：Toll样受体1 基因多态性 胃肿瘤 癌前状态 

分 类 号：R735.2[医药卫生—肿瘤]