病理类型、年龄与宫颈癌术后复发相关性的Meta分析  

The recurrent risk factors of cervical cancer such as histological types and age after surgery:a Meta-analysis

作　　者：韩赛[1] 宗丽菊 李艺[1] 李姗[1] 胡睿[1] 张静静[1] 陈倩[1] 张友忠[1] 

机构地区：[1]山东大学齐鲁医院妇产科,济南250012

出　　处：《现代妇产科进展》2015年第12期923-925,928,共4页Progress in Obstetrics and Gynecology

基　　金：山东省科技发展计划项目(山东省科技攻关计划);国家自然基金项目(No:81572559)

摘　　要：目的:综合评价宫颈癌术后复发与病理类型及年龄的关系。方法:计算机检索2009年4月至2015年4月Pub Med数据库、Elsevier数据库、Springer Link数据库、LWW数据库、CNKI数据库、Cochrane图书馆、Embase数据库、中国生物医学文献数据库、数字化期刊全文数据库(万方)等国内外数据库,纳入研究宫颈癌术后复发危险因素的文献,对资料进行质量评价和数据提取后,采用Cochrane协作网提供的Revman 5.3软件对各研究数据进行合并和分析。结果:检索到符合纳入标准的文献7篇,复发病例466例,未复发病例2473例。Meta分析结果显示,非鳞癌(腺癌和腺鳞癌)和鳞癌的复发率相比较,差异有统计学意义[OR=2.88,95%CI(1.75,4.76),P=0.01];腺癌和腺鳞癌的复发率比较,差异有统计学意义[OR=1.74,95%CI(0.93,3.25),P=0.08];年龄<(47±1)岁和年龄≥(47±1)岁的复发率比较,差异无统计学意义(P<0.05)。结论:不同病理类型的宫颈癌术后复发率非鳞癌大于鳞癌;年龄与宫颈癌患者的术后复发无关。Objective：To evaluate the recurrent risk factors of cervical cancer after surgery comprehensively, such as pathological types and age. Methods：Articles and studies were searched from PubMed database, Elsevier database, Springer Link database, LWW database, CNKI database, Coehrane Library, Embase database, China Biological Medical Literature database, Wang Fang database, and the data were extracted and assessed according to the inclusive and exclusive criteria, then the data input and analyzed by RevMan 5.3 software. Result： Seven case control studies involving 466 recurrences and 2473 non-recurrences after surgery according to the selective criteria were included. Meta-analyses of non-SCC （non-squamous cell carcinoma） and SCC were OR=2.88,95% CI 1.75 -4.76 ,P=0.01 ; Meta-analyses of AC （ adenocarcinoma） and ASC （adenosquamous carcinoma） were OR = 1.74,95% CI O. 93 - 3.25, P = 0.08. Meta-analyses of age showed no significance between the young women （ 〈47±1 ） and the older（ ≥ 47 ＋ 1 ）. Conclusions： These findings demonstrate that the recurrent rate of cervical carcinoma after surgery varies in different histological subtypes：the non-SCC is high than the SCC. In the non-SCC, the AC is high than the ASC. Besides, the age is not related with the recurrence of cervical cancer after surgery.

关 键 词：宫颈癌 术后复发 病理类型 年龄 META分析 

分 类 号：R737.33[医药卫生—肿瘤]