Multipotent mesenchymal stromal cells:A promisingstrategy to manage alcoholic liver disease  

作　　者：Fernando Ezquer Flavia Bruna Sebastián Calligaris Paulette Conget Marcelo Ezquer 

机构地区：[1]Centro de Medicina Regenerativa,Facultad de Medicina,Clínica Alemana-Universidad del Desarrollo,Santiago 7710162,Chile

出　　处：《World Journal of Gastroenterology》2016年第1期24-36,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by No.Fondef Ca13i10088 and No.Fondecyt 1150589

摘　　要：Chronic alcohol consumption is a major cause of liver disease.The term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular carcinoma.With limited therapeutic options,stem cell therapy offers significant potential for these patients.In this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate cells.The perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression.Chronic alcohol consumption is a major cause of liver disease.The term alcoholic liver disease(ALD)refers to a spectrum of mild to severe disorders including steatosis,steatohepatitis,cirrhosis,and hepatocellular carcinoma.With limited therapeutic options,stem cell therapy offers significant potential for these patients.In this article,we review the pathophysiologic features of ALD and the therapeutic mechanisms of multipotent mesenchymal stromal cells,also referred to as mesenchymal stem cells(MSCs),based on their potential to differentiate into hepatocytes,their immunomodulatory properties,their potential to promote residual hepatocyte regeneration,and their capacity to inhibit hepatic stellate cells.The perfect match between ALD pathogenesis and MSC therapeutic mechanisms,together with encouraging,available preclinical data,allow us to support the notion that MSC transplantation is a promising therapeutic strategy to manage ALD onset and progression.

关 键 词：ALCOHOLIC LIVER disease Cellular therapy ALCOHOLIC STEATOHEPATITIS HEPATIC function recovery MESENCHYMAL stem cells 

分 类 号：R575[医药卫生—消化系统]