Hepatitis C virus relies on lipoproteins for its life cycle  

作　　者：Germana Grassi Giorgia Di Caprio Gian Maria Fimia Giuseppe Ippolito Marco Tripodi Tonino Alonzi 

机构地区：[1]National Institute for Infectious Diseases“L.Spallanzani”IRCCS,00149 Rome,Italy [2]Department of Cellular Biotechnologies and Hematology,Pasteur Institute-Cenci Bolognetti Foundation,Sapienza University of Rome,00149 Rome,Italy [3]Department of Biological and Environmental Sciences and Technologies(DiSTeBA),University of Salento,73100 Lecce,Italy

出　　处：《World Journal of Gastroenterology》2016年第6期1953-1965,共13页世界胃肠病学杂志（英文版）

基　　金：Supported by AIRC(to Tripodi M;No.IG-13529 to Fimia GM);Ministry for Health of Italy(“Ricerca Corrente”to Grassi G;Tripodi M;Alonzi T;Fimia GM and Ippolito G;“Ricerca Finalizzata”to Fimia GM and Ippolito G);Ministry of University and Research of Italy(PRIN to Tripodi M;Ph D program to Di Caprio G)

摘　　要：Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence and pathogenesis are due to the ability of HCV to deregulate specific host processes, mainly lipid metabolism and innate immunity. In particular, HCV exploits the lipoprotein machineries for almost all steps of its life cycle. The aim of this review is to summarize current knowledge concerning the interplay between HCV and lipoprotein metabolism. We discuss the role played by members of lipoproteins in HCV entry, replication and virion production.

关 键 词：APOLIPOPROTEINS HEPATITIS C VIRUS LIPIDMETABOLISM LIPOPROTEINS Review 

分 类 号：R373.21[医药卫生—病原生物学]