the Grants-in-Aid for Scientific Research,No.19K16783;the Ministry of Education,Culture,Sports,Science and Technology,Tokyo,Japan,No.20K07454 and No.20K17363;Grant for Promoted Research from Kanazawa Medical University,No.S2018-6.
BACKGROUND Non-alcoholic fatty liver disease(NAFLD),in which abnormal lipid metabolism plays an important role in disease progression,has become a pandemic.Abnormal lipid metabolism,for example an increased fat intake...
National Natural Science Fundation of China (81471232).
OBJECTIVE How infection of Herpes simplex virus typeⅠ(HSV-1) induces enhancement of autophagy.MEHTODS The wild type HSV-1 strain Kos 1.1 was propagated in Vero cells and purified.SK-N-SH cells seeded in DMEM/F12 were...
supported by National Institute of Health Grant HL-48739 and HL-68216
In this review, we focus on the pathway of biogenesis of HDL, the essential role of apoA-I, ATP binding cassette transporter A1(ABCA1), and lecithin: cholesterol acyltransferase(LCAT) in the formation of plasma H...
Supported by AIRC(to Tripodi M;No.IG-13529 to Fimia GM);Ministry for Health of Italy(“Ricerca Corrente”to Grassi G;Tripodi M;Alonzi T;Fimia GM and Ippolito G;“Ricerca Finalizzata”to Fimia GM and Ippolito G);Ministry of University and Research of Italy(PRIN to Tripodi M;Ph D program to Di Caprio G)
Hepatitis C virus(HCV) infects over 150 million people worldwide. In most cases, HCV infection becomes chronic causing liver disease ranging from fibrosis to cirrhosis and hepatocellular carcinoma. Viral persistence a...
Background: Correlations between CRP and serum lipids are weak, and there are conflicting and incomplete results in the literature. The aim of the present study was to clarify the strength and independence of relation...
The aim of this review is to explore the role of mitochondria in regulating macrophage sterol homeostasis and inflammatory responses within the aetiology of atherosclerosis.Macrophage generation of oxysterol activator...
supported by the National Basic Research Program of China(2009CB918300);the National Natural Science Foundation of China(31271189 and 81101009)
A multiplexed targeted proteomic assay using a mTRAQ-MRM/MS-based approach was developed and assessed to systematically quantify the relative expressions of five candidate plasma apolipoproteins that have been previou...
Background: Insulin resistance is linked to dyslipidemia, characterized by a decrease in high density lipo-proteins and an increase in low density lipoproteins. Thiazolidinediones (TZDs) are insulin-sensitizing agents...
Amyloid fibrils arise from the aggregation of misfolded proteins into highly-ordered structures.The accumulation of these fibrils along with some non-fibrillar constituents within amyloid plaques is associated with th...
Supported by the Centrode Investigacion Biomedicaen Reden Enfermedades Hepaticasy Digestivas (CIBERehd)
AIM: To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis. METHODS: Patients with liver cirrhosis of the three most frequent etiologies: hepatitis C virus, hepatitis B virus and alcohol...