THIAZOLIDINEDIONES

作品数:25被引量:81H指数:5
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相关作者:任艳田浩明更多>>
相关机构:西南大学华西医科大学附属第一医院第二军医大学台湾大学更多>>
相关期刊:《Chinese Medical Journal》《World Journal of Cardiology》《World Journal of Diabetes》《Chinese Journal of Chemistry》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划泰国研究基金上海市浦江人才计划项目更多>>
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Peroxisome proliferator-activated receptor gamma as a therapeutic target for hepatocellular carcinoma:Experimental and clinical scenarios被引量:3
《World Journal of Gastroenterology》2022年第28期3535-3554,共20页Swati Katoch Vinesh Sharma Vikram Patial 
CSIR,India,No.MLP0204
Hepatocellular carcinoma(HCC)is the most common type of liver cancer worldwide.Viral hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the HCC....
关键词:ANTICANCER Hepatocellular carcinoma Natural agonists Peroxisome proliferator-activated receptor-γ THIAZOLIDINEDIONES 
Synthesis of Chiral Hydantoins and Thiazolidinediones via Iridium-Catalyzed Asymmetric Hydrogenation
《Chinese Journal of Chemistry》2022年第7期819-824,共6页Yu Nie Jing Li Qianjia Yuan Wanbin Zhang 
supported by the National KeyR&D Programof China(No.2018YFE0126800);National Natural Science Foundation of China(Nos.22001164,21620102003 and 21991112);Shanghai Municipal Education Commission(No.201701070002E00030);Shanghai Pujiang Program(20PJ1406400);the startup funding from Shanghai Jiao Tong University。
Herein,we report an iridium-catalyzed asymmetric hydrogenation of hydantoin and thiazolidinedione derived exocyclic alkenes using our developed BiphPHOX as a ligand.The transformation shows good functional group toler...
关键词:HYDANTOINS THIAZOLIDINEDIONES Phosphine-oxazoline ligand IRIDIUM Asymmetric catalysis 
Effectiveness of drug interventions in nonalcoholic fatty liver disease:A network meta-analysis被引量:2
《World Journal of Diabetes》2021年第9期1576-1586,共11页Yi-Zhou Huang Gang-Yi Yang Cong Wang Xing-Yu Chen Li-Li Zhang 
Supported by National Natural Science Foundation of China,No.81300702;Natural Science Foundation Project of Chongqing CSTC,No.cstc2018jcyjAXO210.
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major chronic liver disorder worldwide,and there is no established treatment for this disease.We conducted a network meta-analysis(NMA)to compare existing treatme...
关键词:Antidiabetic drugs Glucagon-like peptide-1 receptor agonists Nonalcoholic fatty liver disease Network meta-analysis THIAZOLIDINEDIONES 
Clinical effects of antidiabetic drugs on psoriasis:The perspective of evidence-based medicine
《World Journal of Diabetes》2021年第8期1141-1145,共5页Mei-Xian Zhang Bo-Yuan Zheng Hai-Xiao Chen Ching-Wen Chien 
Psoriasis and diabetes shared common underlying pathophysiological mechanisms.Emerging data suggested that antidiabetic medications may improve the psoriasis severity in patients with diabetes mellitus.Several hypogly...
关键词:PSORIASIS Hypoglycemic agents THIAZOLIDINEDIONES Glucagon-like peptide-1 receptor agonists Dipeptidyl peptidase-4 inhibitors BIGUANIDES Antipsoriatic effect Evidence-based medicine 
Controlled clinical trial on the combination therapy with metformin,thiazolidinediones,glucagon-like peptide 1 analog in patients with type 2 diabetes and metabolic syndrome
《China Medical Abstracts(Internal Medicine)》2019年第4期206-206,共1页KANG Zhuang 
Objective To compare the efficacy and safety of metformin/thiazolidinediones(TZDs)/glucagon-like peptide 1(GLP-1)analogs(triple therapy)with conventional glucose-lowering therapy(conventional therapy)for patients with...
关键词:Controlled CLINICAL COMBINATION 
CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss被引量:6
《Genes & Diseases》2018年第3期290-299,共10页Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao 
supported by the National Natural Science Foundation of China(81270947 and 81570763,to XX);the National Program on Key Basic Research Project of China(973 Program,2012CB517505,to XX);the Fundamental Science and Advanced Technology Research of Chongqing(Major Project,CSTC2015jcyjB0146);Chongqing Graduate Student Research Innovation Fund(CYB15095,to HY)。
Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increase...
关键词:OSTEOBLASTS Peroxisome proliferator-activated receptor g THIAZOLIDINEDIONES TR-FRET Type 2 diabetes mellitus 
Peroxisome proliferator activated receptors at the crossroad of obesity, diabetes, and pancreatic cancer被引量:18
《World Journal of Gastroenterology》2016年第8期2441-2459,共19页Simone Polvani Mirko Tarocchi Sara Tempesti Lapo Bencini Andrea Galli 
Supported by Fondo per gli Investimenti della Ricerca di Base;No.RBAP10MY35_002;Ente Cassa di Risparmio di Firenze;and Fior Gen ONLUS to Galli A
Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive gen...
关键词:Insulin Pancreatic cancer Adipose tissue METFORMIN Nuclear receptor LEPTIN ADIPONECTIN Inflammation THIAZOLIDINEDIONES 
Species differences in regulation of renal proximal tubule transport by certain molecules
《World Journal of Nephrology》2015年第2期307-312,共6页George Seki Motonobu Nakamura Masashi Suzuki Nobuhiko Satoh Shoko Horita 
Renal proximal tubules (PTs) play important roles in the regulation of acid/base, plasma volume and blood pressure. Recent studies suggest that there are substantial species differences in the regulation of PT trans...
关键词:Renal proximal tubule THIAZOLIDINEDIONES Peroxisome proliferator activated receptor g INSULIN Angiotensin  Nitric oxide 
Insulin sensitizers for the treatment of non-alcoholic fatty liver disease被引量:14
《World Journal of Hepatology》2014年第4期199-206,共8页Zeynel Abidin Ozturk Abdurrahman Kadayifci 
Non-alcoholic fatty liver disease(NAFLD) is the leading cause of liver disease in the Western world and is closely associated with metabolic syndrome,which includes hypertension,central obesity,dyslipidemia and insuli...
关键词:Insulin SENSITIZERS Metformin Non-alcoholic fatty liver disease Non-alcoholic STEATOHEPATITIS THIAZOLIDINEDIONES 
The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension
《Open Journal of Endocrine and Metabolic Diseases》2013年第5期34-41,共8页Shoko Horita Motonobu Nakamura Masashi Suzuki Hideomi Yamada George Seki 
Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resis...
关键词:INSULIN INFLAMMATION TNF-α PROXIMAL TUBULE INSULIN Resistance PPARγ THIAZOLIDINEDIONES 
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