Hepatocellular carcinoma(HCC)is the most common type of liver cancer worldwide.Viral hepatitis is a significant risk factor for HCC,although metabolic syndrome and diabetes are more frequently associated with the HCC....
supported by the National KeyR&D Programof China(No.2018YFE0126800);National Natural Science Foundation of China(Nos.22001164,21620102003 and 21991112);Shanghai Municipal Education Commission(No.201701070002E00030);Shanghai Pujiang Program(20PJ1406400);the startup funding from Shanghai Jiao Tong University。
Herein,we report an iridium-catalyzed asymmetric hydrogenation of hydantoin and thiazolidinedione derived exocyclic alkenes using our developed BiphPHOX as a ligand.The transformation shows good functional group toler...
Supported by National Natural Science Foundation of China,No.81300702;Natural Science Foundation Project of Chongqing CSTC,No.cstc2018jcyjAXO210.
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major chronic liver disorder worldwide,and there is no established treatment for this disease.We conducted a network meta-analysis(NMA)to compare existing treatme...
Psoriasis and diabetes shared common underlying pathophysiological mechanisms.Emerging data suggested that antidiabetic medications may improve the psoriasis severity in patients with diabetes mellitus.Several hypogly...
Objective To compare the efficacy and safety of metformin/thiazolidinediones(TZDs)/glucagon-like peptide 1(GLP-1)analogs(triple therapy)with conventional glucose-lowering therapy(conventional therapy)for patients with...
supported by the National Natural Science Foundation of China(81270947 and 81570763,to XX);the National Program on Key Basic Research Project of China(973 Program,2012CB517505,to XX);the Fundamental Science and Advanced Technology Research of Chongqing(Major Project,CSTC2015jcyjB0146);Chongqing Graduate Student Research Innovation Fund(CYB15095,to HY)。
Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increase...
Supported by Fondo per gli Investimenti della Ricerca di Base;No.RBAP10MY35_002;Ente Cassa di Risparmio di Firenze;and Fior Gen ONLUS to Galli A
Pancreatic ductal adenocarcinoma (PDAC) is the fourth cause of cancer death with an overall survival of 5% at five years. The development of PDAC is characteristically associated to the accumulation of distinctive gen...
Renal proximal tubules (PTs) play important roles in the regulation of acid/base, plasma volume and blood pressure. Recent studies suggest that there are substantial species differences in the regulation of PT trans...
Non-alcoholic fatty liver disease(NAFLD) is the leading cause of liver disease in the Western world and is closely associated with metabolic syndrome,which includes hypertension,central obesity,dyslipidemia and insuli...
Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resis...