BIGUANIDES

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Biguanides and lactic acidosis:unraveling the complex relationship
《Pharmacology Discovery》2024年第3期48-51,共4页Shreyash Narade 
Biguanides,such as metformin,have long been established as frontline medications for the management of type 2 diabetes due to their glucose-lowering effects and favorable safety profiles.However,concerns regarding the...
关键词：BIGUANIDES METFORMIN lactic acidosis type 2 diabetes PHARMACOVIGILANCE 
Metformin-associated lactic acidosis:A mini review of pathophysiology,diagnosis and management in critically ill patients
《World Journal of Diabetes》2024年第6期1178-1186,共9页Kay Choong See 
Metformin is a common diabetes drug that may reduce lactate clearance by inhibiting mitochondrial oxidative phosphorylation,leading to metforminassociated lactic acidosis(MALA).As diabetes mellitus is a common chronic...
关键词：Acid-base equilibrium BIGUANIDES Oxidative phosphorylation Pyruvic acid Renal replacement therapy 
Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells
《Genes & Diseases》2023年第5期1787-1790,共4页Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou Derek Toomre Junfen Fu Yingke Xu 
supported by the National Key Research and Development Program of China(No.2021YFF0700305);Zhejiang Provincial Natural Science Foundation(No.LZ23H180002,LY18H070004);the Fundamental Research Funds for the Central Universities(China)(No.2021XZZX022);the Zhejiang University Education Foundation Global Partnership Fund(China).
Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 C...
关键词：CANCER FUNCTION TRANSLATIONAL 
Clinical effects of antidiabetic drugs on psoriasis:The perspective of evidence-based medicine
《World Journal of Diabetes》2021年第8期1141-1145,共5页Mei-Xian Zhang Bo-Yuan Zheng Hai-Xiao Chen Ching-Wen Chien 
Psoriasis and diabetes shared common underlying pathophysiological mechanisms.Emerging data suggested that antidiabetic medications may improve the psoriasis severity in patients with diabetes mellitus.Several hypogly...
关键词：PSORIASIS Hypoglycemic agents THIAZOLIDINEDIONES Glucagon-like peptide-1 receptor agonists Dipeptidyl peptidase-4 inhibitors BIGUANIDES Antipsoriatic effect Evidence-based medicine 
Cost-Effectiveness Analysis of Oral Hypoglycemics for Type-2 Diabetes Mellitus at a Tertiary Care Hospital, Nepal
《Journal of Pharmacy and Pharmacology》2019年第10期546-556,共11页Saroj Dhakal Shrijana Shakya Shree Krishna Sharma 
An observational follow-up study on 63 newly diagnosed Type-Ⅱ diabetic patients was conducted at Tribhuvan University Teaching Hospital, a tertiary care centre, Kathmandu, Nepal. The aims of the study were to determi...
关键词：DIABETES milltus cost effectiveness analysis BIGUANIDES SULPHONYLUREAS HBA1C Nepal 
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