Biguanides and lactic acidosis:unraveling the complex relationship  

作　　者：Shreyash Narade 

机构地区：[1]School of Clinical Medicine,Anhui Medical University,Hefei 230032,China

出　　处：《Pharmacology Discovery》2024年第3期48-51,共4页

摘　　要：Biguanides,such as metformin,have long been established as frontline medications for the management of type 2 diabetes due to their glucose-lowering effects and favorable safety profiles.However,concerns regarding the risk of lactic acidosis associated with biguanide use have sparked considerable debate and scrutiny.This research article aims to provide a comprehensive analysis of the relationship between biguanides,particularly metformin,and lactic acidosis.We delve into the underlying mechanisms,epidemiological evidence,risk factors,clinical manifestations,diagnostic considerations,and management strategies related to biguanide-induced lactic acidosis.Additionally,we explore recent research developments,controversies,and future directions in this critical area of pharmacovigilance and clinical practice.

关 键 词：BIGUANIDES METFORMIN lactic acidosis type 2 diabetes PHARMACOVIGILANCE 

分 类 号：R73[医药卫生—肿瘤]