Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells  

作　　者：Yuanfa Yao Hanbing Li Xinyi Wang Yuanhai Sun Xuqin Zhao Weiwei Zha Jiaqiang Zhou Derek Toomre Junfen Fu Yingke Xu 

机构地区：[1]Department of Endocrinology,Children's Hospital of Zhejiang University School of Medicine,National Clinical Research Center for Children's Health,Hangzhou,Zhejiang 310051,China [2]Department of Biomedical Engineering,Key Laboratory of Biomedical Engineering of Ministry of Education,State Key Laboratory of Modern Optical Instrumentation,Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal,Zhejiang University,Hangzhou,Zhejiang 310027,China [3]Institute of Pharmacology,College of Pharmaceutical Science,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China [4]Department of Endocrinology,The Affiliated Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310016,China [5]Department of Cell Biology,Yale University School of Medicine,New Haven,CT 06520,USA [6]Binjiang Institute of Zhejiang University,Hangzhou,Zhejiang 310053,China

出　　处：《Genes & Diseases》2023年第5期1787-1790,共4页基因与疾病（英文）

基　　金：supported by the National Key Research and Development Program of China(No.2021YFF0700305);Zhejiang Provincial Natural Science Foundation(No.LZ23H180002,LY18H070004);the Fundamental Research Funds for the Central Universities(China)(No.2021XZZX022);the Zhejiang University Education Foundation Global Partnership Fund(China).

摘　　要：Phospholipase D(PLD)and its product phosphatidic acid(PA)function as pleiotropic factors in the regulation of cancer progression,which includes the promotion of cell growth,survival,cell migration,and angiogenesis.1 Chemical inhibition of the enzymatic activity of PLD1 and PLD2,or genetic down-regulation of their expression both induce tumor suppression,1 while the compounds for PLD expression inhibition are barely reported.Here,we astonishingly found that the anti-hyperglycemic agents biguanides decreased PLD1 protein expression in cancer cells and further investigated its underlying regulatory mechanism.

关 键 词：CANCER FUNCTION TRANSLATIONAL 

分 类 号：R73[医药卫生—肿瘤]