The Effects of Insulin Resistance and Inflammation on Renal Proximal Tubule Sodium Transport and Hypertension  

作　　者：Shoko Horita Motonobu Nakamura Masashi Suzuki Hideomi Yamada George Seki 

机构地区：[1]Department of Internal Medicine, The University of Tokyo Hospital, Tokyo, Japan

出　　处：《Open Journal of Endocrine and Metabolic Diseases》2013年第5期34-41,共8页内分泌与新陈代谢疾病期刊（英文）

摘　　要：Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resistance may increase renal sodium reabsorption, leading to hypertension, edema and sometimes heart failure. Recently some anti-diabetic agents have been shown to have effects on the transporters in renal proximal tubule. Because renal proximal tubule mediates about 70% of sodium reabsorption, it is quite important to clarify the function of renal proximal tubule under insulin resistance and inflammation.Insulin resistance, closely linked to inflammation, is recognized as a key factor in the onset and aggravation of diabetes, cardio-renal syndrome, hypertension, and obesity. In the renal proximal tubule, insulin resistance may increase renal sodium reabsorption, leading to hypertension, edema and sometimes heart failure. Recently some anti-diabetic agents have been shown to have effects on the transporters in renal proximal tubule. Because renal proximal tubule mediates about 70% of sodium reabsorption, it is quite important to clarify the function of renal proximal tubule under insulin resistance and inflammation.

关 键 词：INSULIN INFLAMMATION TNF-α PROXIMAL TUBULE INSULIN Resistance PPARγ THIAZOLIDINEDIONES 

分 类 号：R5[医药卫生—内科学]