supported by grants from the National Key R&D Program of China(2021YFA1300800);Project for Young Scientists in Basic Research(YSBR-075)of the Chinese Academy of Sciences。
The endoplasmic reticulum(ER)is an essential component of the endomembrane system in eukaryotes and plays a crucial role in protein and lipid synthesis,as well as the maintenance of calcium homeostasis.Morphologically...
supported by the National Natural Science Foundation of China(31870295 and 32170343).
The endoplasmic reticulum(ER)is the processing factory of secretory proteins and the largest membrane-bound organelle with multiple interactions with the other organelles.It is a dynamic network composed of two morpho...
This work was financially supported by National Natural Science Foundation of China(81901043,81970918,and 82001106);J.Yu’s research conducted at the UBC Faculty of Dentistry was supported by China Scholarship Council(202006275049).
As a global public health focus,oral health plays a vital role in facilitating overall health.Defected teeth characterized by exposure of dentin generally increase the risk of aggravating oral diseases.The exposed den...
the National Key R&D Program of China(2018YFC1312700);the National Naturai Science Foundation of China(831730043);the Program of Innovative Research Team of the National Natural Science Foundation(81721001);Program for Changjiang Scholars and Innovative Research Team in University(IRT1216);Key Research and Development Projects of Science and Technology Innovation of Social and People's Livelihood in Chongqing City,(cstc2018jscx-mszdX0024);Clinical Medical Research Talent Training Program from The Third Military Medical University(2018XLCi012);National Institutes of Health,USA(P01HL074940,DK039308,and DK119652).
Objective:Dopamine,via its receptors,plays a vital role in the maintenance of blood pressure by modulating renal sodium transport.However,the role of the D_(4)dopamine receptor(D_(4)receptor)in renal proximal tubules(...
Mice deficient in the transcription factor pleomorphic adenoma gene 1(PLAG1)exhibit reproductive issues that are characterized,in part,by decreased progressive sperm motility in the male.However,the underlying cause o...
Disturbances in acid-base balance leading to the development of hypertension are currently gaining increased attention among researchers. Perturb acid-base balance characterized by metabolic acidosis has been demonstr...
Objective To demonstrate that intravoxel incoherent motion(IVIM)imaging can assess temporal renal functional changes in contrast-induced acute kidney injury(CI-AKI).Methods Twenty-seven male Sprague-Dawley(SD)rats wit...
Acknowledgements This work was supported by the Scientific Research Foundation of Shanghai Jiao Tong University School of Medicine (No 12XJ3008, Jiang HONG), the National Natural Science Foundation of China (No 81570293, Jiang HONG), and the United States National Heart, Lung and Blood Institute (No R01 HL090905, Long-sheng SONG),
Aim: Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, has been shown to exert beneficial effects in heart failure. The purpose of this study was to test whether sildenafil suppressed transverse-tubule (T-tubule...
Supported by National Institutes of Health,No.DP2 OD008470;Private funding was provided from the University of Notre Dame College of Science and Graduate School;a generous donation to support stem cell research provided by the Gallagher Family
Kidney disease is an escalating global health problem,for which the formulation of therapeutic approaches using stem cells has received increasing research attention.The complexity of kidney anatomy and function,which...
supported by grants from the National Natural Science Foundation of China(No.81172826);Collaborative Innovation Center of Hematology,China
Acute graft-versus-host disease(a GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation(allo-HSCT). However,the mechanisms of a GVHD are not well understood. We aim to investigat...