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作品数：290被引量：466H指数：11
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相关领域：医药卫生更多>>
相关作者：魏建民张峰赵国芬张萍李源更多>>
相关机构：浙江传化股份有限公司中国中化集团公司杭州传化精细化工有限公司东华大学更多>>
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Unveiling and swift diagnosing chronic wound healing with artificial intelligence assistance
《Chinese Chemical Letters》2025年第3期469-475,共7页Jiliang Deng Guoliang Shi Zhihang Ye Quan Xiao Xiaoting Zhang Lei Ren Fangyu Yang Miao Wang 
supported by the Fundamental Research Funds for the Central Universities(No.20720230037);the National Natural Science Foundation of China(No.52273305);Natural Science Foundation of Fujian Province of China(No.2023J05012);State Key Laboratory of Vaccines for Infectious Diseases,Xiang An Biomedicine Laboratory(Nos.2023XAKJ0103071,2023XAKJ0102061);Natural Science Foundation of Xiamen,China(No.3502Z20227010).
Histopathological analysis of chronic wounds is crucial for clinicians to accurately assess wound healing progress and detect potential malignancy.However,traditional pathological tissue sections require specific stai...
关键词：Chronic wound Virtual pathological staining AI-assisted diagnostic and therapeutic Gel dressings 
Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry andπ-bridge effect design philosophy
《Science China Chemistry》2025年第3期1041-1050,共10页Qiong Liu Qiyun Deng Changxu Zhu Kongqi Chen Lidan Chen Zhaohui Sun Ben Zhong Tang Zhiming Wang 
supported by the National Natural Science Foundation of China (52473173);Natural Science Foundation of Guangdong Province (2022B1515020084);Guangdong Basic and Applied Basic Research Foundation (2023B1515040003);Key Project of Yunnan Provincial Department of Science and Technology (202303AC100021);Independent Research Project of State Key Lab of Luminescent Materials and Devices (SCUT) (Skllmd-2024-10);Key-Area Research and Development Program of Guangdong Province (2024B0101040001)。
The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging task.In this study,we successfully constructed three novel fluorescent probe...
关键词：aggregation-induced emission π-bridge effect photodynamic therapy fluorescent probes 
Enhanced multiscale human brain imaging by semi-supervised digital staining and serial sectioning optical coherence tomography
《Light(Science & Applications)》2025年第2期490-508,共19页Shiyi Cheng Shuaibin Chang Yunzhe Li Anna Novoseltseva Sunni Lin Yicun Wu Jiahui Zhu Ann C.McKee Douglas L.Rosene Hui Wang Irving J.Bigio David A.Bas Lei Tan 
funding support from:National Institutes of Health grant R01 EY032163(S.C.,L.T);National Institutes of Health grant U54 NS115266(A.C.M.);National Institutes of Health grant P30 AG072978(A.C.M.);National Institutes of Health grant U19 AG068753(A.C.M.);National Institutes of Health grant R01 NS125307(D.L.R.);National Institutes of Health grant RO1 AG075727(D.L.R.and IJ.B);National Institutes of Health grant RF1 AG062831(D.L.R.);Boston University Kilachand Fund Award(I.J.B.,D.L.R.,D.A.B.,and L.T.);National Institutes of Health grant R00 EB023993(HW);National Institutes of Health grant R01 NS128843(H.W.);National Institutes of Health grant U01 MH117023(S.C.,A.N.,D.A.B.)。
A major challenge in neuroscience is visualizing the structure of the human brain at different scales.Traditional histology reveals micro-and meso-scale brain features but suffers from staining variability,tissue dama...
关键词：NEUROSCIENCE machine learning optical coherence tomography digital staining d imaging histological interpretability visualizing structure d reconstructionsthe 
Exploring the Role of Immunohistochemistry as a Complementary Diagnostic Tool in Burundi
《Journal of Biosciences and Medicines》2025年第1期284-299,共16页Ndayikengurukiye Omar Helmy Bin Hazmi Isabel Lim Fong Ngendahayo Louis Irangabiye Eloi 
This study investigates the variability in cancer diagnosis across different tissues and organs, with a focus on the role of diagnostic methods such as Hematoxylin and Eosin (H&E) staining and immunohistochemistry (IH...
关键词：Cancer Diagnosis Hematoxylin and Eosin (H&E) Staining Immunohistochemistry (IHC) Diagnostic Protocols Diagnostic Gaps Routine Diagnostics Cancer Prevalence 
Cross-modality transformations in biological microscopy enabled by deep learning
《Advanced Photonics》2024年第6期13-33,共21页Dana Hassan Jesús Domínguez Benjamin Midtvedt Henrik Klein Moberg Jesús Pineda Christoph Langhammer Giovanni Volpe Antoni Homs Corber Caroline B.Adiels 
support from the MSCA-ITN-ETN project ActiveMatter sponsored by the European Commission(Horizon 2020,Project No.812780);support from the ERC-CoG project MAPEI sponsored by the European Commission(Horizon 2020,Project No.101001267);from the Knut and AliceWallenberg Foundation(Grant No.2019.0079);aroline Beck Adiels and Giovanni Volpe acknowledge the Swedish Foundation for Strategic Research(Grant No.ITM17-0384).
Recent advancements in deep learning(DL)have propelled the virtual transformation of microscopy images across optical modalities,enabling unprecedented multimodal imaging analysis hitherto impossible.Despite these str...
关键词：cross-modality transformations virtual staining SUPERRESOLUTION deep learning fluorescence bright-field phase contrast 
Rapid and Efficient Investigation of Ciliate Nuclear Development During Conjugation Through Optimizing Hoechst33342 Staining Workflow
《Journal of Ocean University of China》2024年第6期1666-1676,共11页JIANG Yaohan ZHANG Xue LIU Dan TANG Xianglin GONG Ruitao 
supported by the National Natural Science Foundation of China(No.32270558)。
Ciliates are eukaryotic unicellular organisms with complex morphology and developmental processes,including asexual and sexual processes.Conjugation is a form of sexual process that renews genetic materials.However,vi...
关键词：CILIATES CONJUGATION nucleus CYTOLOGY Hoechst33342 staining 
CellVisioner:A Generalizable Cell Virtual Staining Toolbox based on Few-Shot Transfer Learning for Mechanobiological Analysis
《Research》2024年第4期127-137,共11页Xiayu Xu Zhanfeng Xiao Fan Zhang Changxiang Wang Bo Wei Yaohui Wang Bo Cheng Yuanbo Jia Yuan Li Bin Li Hui Guo Feng Xu 
supported by the National Natural Science Foundation of China(12225208);Shaanxi Natural Science Foundation of China(2023-YBGY-233).
Visualizing cellular structures especially the cytoskeleton and the nucleus is crucial for understanding mechanobiology,but traditional fluorescence staining has inherent limitations such as phototoxicity and photoble...
关键词：LIMITATIONS CELL TOOLBOX 
Deep learning-based virtual staining,segmentation,and classification in label-free photoacoustic histology of human specimens
《Light(Science & Applications)》2024年第10期2353-2366,共14页Chiho Yoon Eunwoo Park Sampa Misra Jin Young Kim Jin Woo Baik Kwang Gi Kim Chan Kwon Jung Chulhong Kim 
supported by the following sources:Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(2020R1A6A1A03047902);NRF grant funded by the Ministry of Science and ICT(MSIT)(2023R1A2C3004880,2021M3C1C3097624);Korea Medical Device Development Fund grant funded by the Korea government(MSIT,the Ministry of Trade,Industry and Energy,the Ministry of Health&Welfare,the Ministry of Food and Drug Safety)(Project Number:1711195277,RS-2020-KD000008,1711196475,RS-2023-00243633);Institute of Information&communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.RS-2019-II191906,Artificial Intelligence Graduate School Program(POSTECH));BK21 FOUR program.
In pathological diagnostics,histological images highlight the oncological features of excised specimens,but they require laborious and costly staining procedures.Despite recent innovations in label-free microscopy tha...
关键词：STEPWISE Deep SPITE 
Personalized laparoscopic radical resection of gallbladder cancer by staining of the liver draining area through ICG injection into the cholecystic artery
《Cancer Biology & Medicine》2024年第10期844-848,共5页Xu Bao Dongyang Li Wei Zhang 
supported by grants from Tianjin Medical University Cancer Hospital,Precision Treatment Technology Construction Project for Cancer Surgery(Grant No.ZLWKJZZL14);from Zhongguancun Precision Medicine Foundation,Medical and Health Public Welfare-Cancer Medical Research Special Project(Grant No.ZGC-YXKYZL004).
Gallbladder cancer(GBC)is a common malignant tumor often diagnosed in advanced stages.Surgery is among the most important treatments for GBC.Radical resection of GBC involves removal of the gallbladder and the gallbla...
关键词：GALLBLADDER INJECTION Surgery 
Predictors of cerebrospinal fluid GeneXpert MTB/RIF positivity in patients with tuberculous meningitis:A prospective cohort study
《Asian Pacific Journal of Tropical Medicine》2024年第10期465-472,共8页Priyanka Gupta Neeraj Kumar Ravindra Kumar Garg Hardeep Singh Malhotra Imran Rizvi Rajesh Verma Praveen Kumar Sharma Ravi Uniyal Shweta Pandey Amita Jain Parul Jain 
Objective:To identify the clinical,laboratory,and radiological markers that could predict a positive GeneXpert result in patients suspected of tuberculous meningitis.Methods:In this prospective,observational study,pat...
关键词：Tuberculous meningitis Mycobacterium tuberculosis Cerebrospinal fluid Ziehl-Neelsen staining GeneXpert 
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