Specific staining and precise killing of cancer cells through fusion of pharmaceutical chemistry andπ-bridge effect design philosophy  

作　　者：Qiong Liu Qiyun Deng Changxu Zhu Kongqi Chen Lidan Chen Zhaohui Sun Ben Zhong Tang Zhiming Wang 

机构地区：[1]AIE Institute,Center for Aggregation-Induced Emission,State Key Laboratory of Luminescent Materials and Devices,Key Laboratory of Luminescence from Molecular Aggregates of Guangdong Province,South China University of Technology,Guangzhou 510640,China [2]School of Life Sciences,The Chinese University of Hong Kong,Hong Kong 999077,China [3]Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen,Shenzhen 518172,China [4]HKUST-Shenzhen Research Institute,Shenzhen 518057,China [5]Department of Laboratory Medicine General Hospital of Southern Theater Command,Guangzhou 510010,China

出　　处：《Science China Chemistry》2025年第3期1041-1050,共10页中国科学(化学英文版)

基　　金：supported by the National Natural Science Foundation of China (52473173);Natural Science Foundation of Guangdong Province (2022B1515020084);Guangdong Basic and Applied Basic Research Foundation (2023B1515040003);Key Project of Yunnan Provincial Department of Science and Technology (202303AC100021);Independent Research Project of State Key Lab of Luminescent Materials and Devices (SCUT) (Skllmd-2024-10);Key-Area Research and Development Program of Guangdong Province (2024B0101040001)。

摘　　要：The development of an advanced phototheranostic platform that combines imaging and therapy in a single agent is an appealing yet challenging task.In this study,we successfully constructed three novel fluorescent probes by leveraging pharmaceutical chemistry and the design philosophy of theπ-bridge effect.Through a systematic comparative analysis of their fluorescence properties,water solubility,molecular conformation,and electrostatic potential,we revealed the fundamental principles governing the optical behavior and biological selectivity of these probes.Notably,the probe TPh IQ-CNTh demonstrated extended fluorescence in the near-infrared region,a significant aggregation-induced emission(AIE)effect,and the ability to distinguish tumor cells from normal cells.Moreover,it efficiently generated reactive oxygen species(ROS)and specifically labeled lipid droplets,enabling the precise staining and killing of cancer cells.This study presents a practical strategy for designing precise tumor treatments that integrate efficient imaging-guided photodynamic therapy(PDT)by harnessing the unique properties of AIE materials.

关 键 词：aggregation-induced emission π-bridge effect photodynamic therapy fluorescent probes 

分 类 号：R73-36[医药卫生—肿瘤]