supported by the National Natural Science Foundation of China(82271347 to GJW);the Major project of Wenzhou Science and Technology Bureau(ZY2020016 to GJW).
Hypertension is a prominent contributor to vascular injury.Deubiquinatase has been implicated in the regulation of hypertension-induced vascular injury.In the present study we investigated the specific role of deubiqu...
Chongqing Science and Health Joint Medical ResearchProject,Grant/AwardNumber:2024MSXM124。
Cerebral ischemia-reperfusion(I/R)injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke(AIS).It has been found that the brain renin-angiotensin system,especially the...
supported by the National Natural Science Foundation of China(81871973 to SHZ);the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(2020xkjT023 to HQ).
The angiotensin Ⅱ type 2 receptor(AT2R)is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage.Pharmacological a...
BACKGROUND The initial trials on angiotensin Ⅱ(AT Ⅱ)administration indicated a high incidence of thrombocytopenia and thrombosis,as well as a positive correlation between hyperreninemia and response to the medicatio...
Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 virus.It has affected over 768 million people worldwide,result...
supported by Spanish Ministry of Science and Innovation(PID2021-126848NB-I00,PLEC2022-009401);Instituto de Salud CarlosⅢ(RD21/0017/0031;PI20/00345,and CIBERNED);Galician Government(XUGA,ED431C 2022/41),and FEDER(Regional European Development Fund).
The renin-angiotensin system(RAS)was classically considered a circulating hormonal system that regulates blood pressure.However,different tissues and organs,including the brain,have a local paracrine RAS.Mutual regula...
In this study,Ulva prolifera protein was used for preparing angiotensin-I converting enzyme(ACE)-inhibitory peptide via virtual gastrointestinal digestion and in silico screening.Some parameters of the obtained peptid...