ANGIOTENSIN

作品数：511被引量：1582H指数：16
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相关领域：医药卫生更多>>
相关作者：张静陈丽萌金振刚王晶盛灵慧更多>>
相关机构：上海交通大学首都医科大学复旦大学中山大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金北京市自然科学基金更多>>
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Endothelial FOSL1 drives angiotensin Ⅱ-induced myocardial injury via AT1R-upregulated MYH9
《Acta Pharmacologica Sinica》2025年第4期922-939,共18页Wen-jing Zhao Yi Qian Yi-feng Zhang Ai-hua Yang Jia-xin Cao Hong-yan Qian Yi Liu Wei-zhong Zhu 
funded by grants(82102784 and 81770440)from the National Natural Science Foundation of China;funded by Health Committee of Nantong(MS2023055 and MSZ2023041);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_3440).
Vascular remodeling represents a pathological basis for myocardial pathologies,including myocardial hypertrophy and myocardial infarction,which can ultimately lead to heart failure.The molecular mechanism of angiotens...
关键词：angiotensinⅡ myocardial ischemia-reperfusion FOS like-1(FOSL1) myosin heavy chain 9(MYH9) endothelial cell transcription activation 
Endothelial deubiquinatase YOD1 mediates AngⅡ-induced vascular endothelial-mesenchymal transition and remodeling by regulatingβ-catenin
《Acta Pharmacologica Sinica》2024年第8期1618-1631,共14页Wan-te Lin Yu-cheng Jiang Yi-lin Mei Yang-hao Chen Zhao-zheng Zheng Xue Han Gao-jun Wu Wei-jian Huang Bo-zhi Ye Guang Liang 
supported by the National Natural Science Foundation of China(82271347 to GJW);the Major project of Wenzhou Science and Technology Bureau(ZY2020016 to GJW).
Hypertension is a prominent contributor to vascular injury.Deubiquinatase has been implicated in the regulation of hypertension-induced vascular injury.In the present study we investigated the specific role of deubiqu...
关键词：YOD1 vascular remodeling Β-CATENIN endothelial-mesenchymal transition deubiquitinating enzyme angiotensinⅡ 
The role of angiotensinⅡtype 1 receptor pathway in cerebral ischemia-reperfusion injury:Implications for the neuroprotective effectof ARBs
《Neuroprotection》2024年第2期100-119,共20页Shuhan Huang Meng Zhang 
Chongqing Science and Health Joint Medical ResearchProject,Grant/AwardNumber:2024MSXM124。
Cerebral ischemia-reperfusion(I/R)injury is a crucial factor that impacts the prognosis of recanalization therapy for acute ischemic stroke(AIS).It has been found that the brain renin-angiotensin system,especially the...
关键词：acute ischemic stroke angiotensinⅡtype 1receptor blocker ischemia-reperfusion injury NEUROINFLAMMATION oxidative stress 
服用血管紧张素受体脑啡肽酶抑制剂的患者是否可以临时叠加应用卡托普利?被引量：1
《中华高血压杂志（中英文）》2024年第6期525-528,共4页马志毅 
杨长杰(湖南师范大学附属衡阳市中心医院心内科,湖南衡阳421001)血管紧张素受体脑啡肽酶抑制剂(angiotensin receptor neprilysin inhibitor,ARNI)是一种同时作用于肾素-血管紧张素-醛固酮系统(renin-angiotensin-aldosterone system,RA...
关键词：血管紧张素受体脑啡肽酶抑制剂 衡阳市中心医院 RAAS 卡托普利 湖南衡阳 ANGIOTENSIN 心内科 新型药物 
Angiotensin Ⅱ type-2 receptor signaling facilitates liver injury repair and regeneration via inactivation of Hippo pathway
《Acta Pharmacologica Sinica》2024年第6期1201-1213,共13页Chang-yong Xu Ji Jiang Yue An Peng-fei Ye Cun-cun Zhang Ning-ning Sun Sai-nan Miao Meng-qi Chai Wen-min Liu Mei Yang Wei-hua Zhu Jing-jing Yu Man-man Yu Wu-yi Sun Huan Qiu Shi-hao Zhang Wei Wei 
supported by the National Natural Science Foundation of China(81871973 to SHZ);the Basic and Clinical Cooperative Research and Promotion Program of Anhui Medical University(2020xkjT023 to HQ).
The angiotensin Ⅱ type 2 receptor(AT2R)is a well-established component of the renin-angiotensin system and is known to counteract classical activation of this system and protect against organ damage.Pharmacological a...
关键词：angiotensinⅡtype 2 receptor liver injury liver regeneration Hippo pathway Yap 
Angiotensin Ⅱ administration in severe thrombocytopenia and chronic venous thrombosis:A case report
《World Journal of Critical Care Medicine》2024年第4期112-117,共6页Ana Vujaklija Brajkovic Andrej Markota Luka Bielen Andro Vujević Mia Rora Radovan Radonic 
BACKGROUND The initial trials on angiotensin Ⅱ(AT Ⅱ)administration indicated a high incidence of thrombocytopenia and thrombosis,as well as a positive correlation between hyperreninemia and response to the medicatio...
关键词：Vasodilatory shock AngiotensinⅡ THROMBOCYTOPENIA THROMBOSIS RENIN Case report 
Role of renin-angiotensin system/angiotensin converting enzyme-2 mechanism and enhanced COVID-19 susceptibility in type 2 diabetes mellitus被引量：1
《World Journal of Diabetes》2024年第4期606-622,共17页Ashwin Kumar Shukla Komal Awasthi Kauser Usman Monisha Banerjee 
Coronavirus disease 2019(COVID-19)is a disease that caused a global pandemic and is caused by infection of severe acute respiratory syndrome coronavirus 2 virus.It has affected over 768 million people worldwide,result...
关键词：Angiotensin-converting enzyme 2 Angiotensin-converting enzyme inhibitors Angiotensin-II receptor blockers Complex diseases COVID-19 Type 2 diabetes 
The role of the brain renin-angiotensin system in Parkinson's disease被引量：1
《Translational Neurodegeneration》2024年第1期809-827,共19页Jose Luis Labandeira-Garcia Carmen M.Labandeira Maria J.Guerra Ana I.Rodriguez-Perez 
supported by Spanish Ministry of Science and Innovation(PID2021-126848NB-I00,PLEC2022-009401);Instituto de Salud CarlosⅢ(RD21/0017/0031;PI20/00345,and CIBERNED);Galician Government(XUGA,ED431C 2022/41),and FEDER(Regional European Development Fund).
The renin-angiotensin system(RAS)was classically considered a circulating hormonal system that regulates blood pressure.However,different tissues and organs,including the brain,have a local paracrine RAS.Mutual regula...
关键词：ANGIOTENSIN DOPAMINE NADPH-OXIDASE NEURODEGENERATION Neuroprotection NEUROINFLAMMATION Oxidative stress PARKINSON 
单不饱和脂肪酸作用机制及在糖尿病肾脏疾病中的研究进展被引量：3
《中国中西医结合肾病杂志》2024年第3期274-276,共3页张雁宇 吕欣 黄晓光 任小军 王雪 于为民 
糖尿病肾脏疾病(diabetes kidney disease,DKD)是一种由糖尿病引起的慢性肾脏病,也是引起终末期肾病的主要原因,因此,加强DKD的防治具有重要的意义。研究表明血管紧张素转化酶抑制剂(angiotensin-converting enzyme inhibitors,ACEI)和...
关键词：血管紧张素转化酶抑制剂 糖尿病肾脏疾病 慢性肾脏病 终末期肾病 血管紧张素受体阻滞剂 单不饱和脂肪酸 ANGIOTENSIN 肾功能 
生物医药治疗高血压的时代曙光初露——评zilebesiran临床研究被引量：2
《中华高血压杂志（中英文）》2024年第2期101-103,共3页张新军 
2023年11月11日在美国心脏协会(American Heart Association,AHA)科学年会上发布的zilebesiranⅡ期临床研究结果引人关注。该研究是今年早前于《新英格兰医学杂志》公开发表的Ⅰ期临床研究的后续研究。已发表的zilebesiran研究成果可能...
关键词：美国心脏协会 Ⅱ期临床研究 Ⅰ期临床研究 生物医药 治疗高血压 ANGIOTENSIN 科学进展 
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