TR-FRET

作品数：5被引量：7H指数：1
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相关领域：医药卫生一般工业技术更多>>
相关作者：陈学元涂大涛沈万秋张毅孙艳华更多>>
相关机构：中国科学院中国科学院福建物质结构研究所华中科技大学哈佛学院更多>>
相关期刊：《Acta Pharmacologica Sinica》《Genes & Diseases》《天津医科大学学报》《Journal of Molecular Cell Biology》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金福建省杰出青年科学基金更多>>
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A multiplexed time-resolved fluorescence resonance energy transfer ultrahigh-throughput screening assay for targeting the SMAD4–SMAD3–DNA complex
《Journal of Molecular Cell Biology》2023年第11期21-32,共12页Wukun Ouyang Qianjin Li Qiankun Niu Min Qui Haian Fu Yuhong Du Xiulei Mo 
supported by the National Cancer Institute(NCI)MERIT Award(R37CA255459 to X.M.);NCI Emory Lung Cancer SPORE(P50CA217691 to H.F.)Career Enhancement Program(P50CA217691 to X.M.);NCI Emory Lung Cancer P01(P01CA257906 to H.F.);NCI Office of Cancer Genomics Cancer Target Discovery and Development(CTD2)initiative network(U01CA217875 to H.F.);Winship Cancer Institute(NIH 5P30CA138292).
The transforming growth factor-beta(TGFβ)signaling pathway plays crucial roles in the establishment of an immunosuppressive tumor microenvironment,making anti-TGFβagents a significant area of interest in cancer immu...
关键词：TGFβ/SMAD4 signaling high-throughput screening TR-FRET 
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS
《Journal of Molecular Cell Biology》2023年第3期32-43,共12页Danielle Cicka Qiankun Niu Min Qui Kun Qian Eric Miller Dacheng Fan Xiulei Mo Andrey AIvanov Stefan GSarafianos Yuhong Du Haian Fu 
supported in part by the Emory School of Medicine COVID Catalyst-I3 award(H.F.and S.G.S.);the NCI Emory Lung Cancer SPORE(P50CA217691)Career Enhancement Program(A.A.I.);Emory Initiative on Biological Discovery through Chemical Innovation(A.A.I.);R01AI167356(S.G.S.).
SARS-CoV-2,the coronavirus that causes the disease COVID-19,has claimed millions of lives over the past 2 years.This demands rapid development of effective therapeutic agents that target various phases of the viral re...
关键词：SARS-CoV-2 COVID-19 protein-protein interaction TMPRSS2 SPIKE high-throughput screening TR-FRET 
Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening被引量：1
《Acta Pharmacologica Sinica》2020年第2期286-292,共7页Feng-cai Zhang Zhong-ya Sun Li-ping Liao Yu Zuo Dan Zhang Jun Wang Yan-tao Chen Sen-hao Xiao Hao Jiang Tian Lu Pan Xu Li-yan Yue Dao-hai Du Hao Zhang Chuan-peng Liu Cheng Luo 
the National Natural Science Foundation of China(91853205 and 81625022 to CL,81430084 to DHD);KC Wong Education Foundation to CL,Chinese Academy of Sciences(XDA12020353 to CL and CASIMM0120184015 to HZ);China Postdoctoral Science Foundation(2017M621571 to LYY);Science and Technology Commission of Shanghai Municipality(18431907100 and 19XD1404700 to CL);National Science&Technology Major Project of China(2018ZX09711002 to DHD).
The cAMP-responsive element binding protein(CREB)binding protein(CBP)and adenoviral E1A-binding protein(P300)are two closely related multifunctional transcriptional coactivators.Both proteins contain a bromodomain(BrD...
关键词：CBP BROMODOMAIN SMALL-MOLECULE inhibitor HIGH-THROUGHPUT screening TR-FRET molecular modeling human LEUKEMIA MV4-11 cells 
CMHX008,a PPAR γ partial agonist,enhances insulin sensitivity with minor influences on bone loss被引量：6
《Genes & Diseases》2018年第3期290-299,共10页Yi Hou Xuemei Cao Xiangnan Hu Xinyu Li Xiaoqin Shi Hongying Wang Chuan Peng Jiayu Li Jibin Li Qifu Li Chaodong Wu Xiaoqiu Xiao 
supported by the National Natural Science Foundation of China(81270947 and 81570763,to XX);the National Program on Key Basic Research Project of China(973 Program,2012CB517505,to XX);the Fundamental Science and Advanced Technology Research of Chongqing(Major Project,CSTC2015jcyjB0146);Chongqing Graduate Student Research Innovation Fund(CYB15095,to HY)。
Traditional thiazolidinediones(TZDs),such as rosiglitazone,are peroxisome proliferator-activated receptor g(PPARg)potent agonists that can be used to treat type 2 diabetes but carry unwanted effects,including increase...
关键词：OSTEOBLASTS Peroxisome proliferator-activated receptor g THIAZOLIDINEDIONES TR-FRET Type 2 diabetes mellitus 
基于纳米粒子的TR-FRET传感器用于miRNAs的无扩增检测
《天津医科大学学报》2015年第6期521-524,529,共5页张毅 谭加兴 叶彦恺 姜炜 孙艳华 沈万秋 曹海燕 靳美娜 秦楠 段宏泉 
国家自然科学基金资助项目(21305103;21373151;31200753;21205087)
目的:建立一种基于纳米粒子的时间分辨(TR)荧光共振能量转移(FRET)生物传感器用于mi RNAs的无扩增检测。方法:以寡核苷酸单链probe I偶联Gd F3:Tb3+纳米粒子作为供体,以寡核苷酸单链probe II偶联金(Au)纳米粒子作为受体,利用供体与受体...
关键词：镧系金属掺杂 纳米粒子 时间分辨 荧光共振能量转移 传感器 无扩增检测 
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