云南高校图书馆联盟文献共享服务平台- BROMODOMAIN

BROMODOMAIN: 作品数：44被引量：48H指数：3; 导出分析报告; 相关作者：张智敏陈红丽陈亚东陆涛周洁更多>>; 相关机构：中国科学技术大学中国药科大学中南大学北京工业大学更多>>; 相关期刊：《Signal Transduction and Targeted Therapy》《中国实验血液学杂志》《河北农业大学学报》《Genes & Diseases》更多>>; 相关基金：国家自然科学基金江苏省“青蓝工程”基金资助项目广东省自然科学基金中国博士后科学基金更多>>

BET inhibitors potentiate melanoma ferroptosis and immunotherapy through AKR1C2 inhibition: 《Military Medical Research》2024年第4期620-624,共5页Yu Meng Hui-Yan Sun Yi He Qian Zhou Yi-Huang Liu Hui Su Ming-Zhu Yin Fu-Rong Zeng Xiang Chen Guang-Tong Deng; This work was supported by grants from the National Natural Science Foundation of China(82103183,82102803,82272849);the Natural Science Foundation of Hunan Province(2022JJ40767,2021JJ40976);the Natural Science Fund for Outstanding Youths in Hunan Province(2023JJ20093);the National Key Research and Development Program(2022YFC2504700).; Dear Editor,Ferroptosis,an iron-dependent form of cell death driven by overwhelming lipid peroxidation,represents a vulnerability in cancers,and therapeutic strategies to further potentiate ferroptosis hold great pote...; 关键词：MELANOMA Bromodomain and extra terminal domain(BET)inhibitor Ferroptosis Cell death AKR1C2 IMMUNOTHERAPY

Bromodomain and extraterminal (BET) proteins: biological functions, diseases, and targeted therapy被引量：1: 《Signal Transduction and Targeted Therapy》2023年第12期5631-5656,共26页Zhi-Qiang Wang Zhao-Cong Zhang Yu-Yang Wu Ya-Nan Pi Sheng-Han Lou Tian-Bo Liu Ge Lou Chang Yang; supported by the National Natural Science Foundation of China(nos.81872507 and 82173238);the Heilongjiang Provincial Natural Science Foundation Key Projects(ZD2020H007);the Harbin Medical University Cancer Hospital(CN)Nn10 Project(Nn10py2017-01);the China Postdoctoral Science Foundation(296266);the Heilongjiang Province Doctoral Post-doctoral Fund(LBH-Z21177);the Fundamental Research Funds for the Provincial Universities(2022-KYYWF-0291);the Harbin Medical University Haiyan Youth Fund(JJQN2022-3).; BET proteins,which influence gene expression and contribute to the development of cancer,are epigenetic interpreters.Thus,BET inhibitors represent a novel form of epigenetic anticancer treatment.Although preliminary c...; 关键词：DRUGS holds meaningful

基于ZAc热点区域的BRD4 Bromodomain抑制剂设计与活性研究被引量：1: 《Journal of Chinese Pharmaceutical Sciences》2023年第12期971-988,共18页李慧丽李珏何丹丹陶玲江渝斌沈祥春姜飞; Guizhou Province Ordinary Colleges and Universities Youth Science and Technology Talent Growth Project (Grant No. QJH-KY[2022]249, QJH-KY[2022]250);Science and Technology Fund of Guizhou Provincial Health Commission (Grant No. GZWKJ2022-464 and GZWKJ2022-466);the Basic Research Program of Guizhou Province,Guizhou Provience Science and Technology Foundation,China (Grant No. QKHJC-ZK[2021]YB553, QKHRCZK[2023]YB308, and QKHJC-ZK[2023]ZD035);Cultivation Project of National Natural Science Foundation of Guizhou Medical University (Grant No. 20NSP052);The Start-up Foundation for Doctors of Guizhou Medical University (Grant No. YJ2020-BK035);Provincial College Student Innovation,Entrepreneurship Training Program (Grant No. S202010660142);the Guizhou Provincial Scientific and Technologic Innovation Base (Grant No.[2023]003);the National Natural Science Foundation of China (Grant No. 22307026)。; Bromodomain是一种表观遗传读取器,在识别乙酰化组蛋白方面发挥关键功能而越来越受到关注。Bromodomain结构域的蛋白质与多种疾病的发展有关,靶向Bromodomain结构域已成为开发蛋白质-蛋白质相互作用抑制剂的重要策略。本研究在BRD4的乙...; 关键词：蛋白-蛋白相互作用 BRD4 ZAc区域急性髓性白血病细胞

关于Bromodomain如何翻译的建议: 《中国临床药理学杂志》2023年第20期3021-3021,共1页; 在中文文献中,Bromodomain被翻译为溴结构、是因为词中含有Bromo词根。那么Bromodomain中的Bromo是指溴吗?如果是,细胞生物学中并没有提到生命中有溴元素参与,为什么叫溴结构域?; 关键词：细胞生物学中文文献结构域溴翻译

Potent bromodomain and extraterminal domain inhibitor JAB-8263 suppresses MYC expression and exerts anti-tumor activity in colorectal cancer models: 《World Journal of Gastrointestinal Oncology》2023年第2期332-342,共11页Xin-Mo Liu Shao-You Xia Wei Long Hai-Jun Li Gui-Qun Yang Wen Sun Song-Yan Li Xiao-Hui Du; Supported by the National Natural Science Foundation of China,No.81871317.; BACKGROUND The overexpression of the MYC gene plays an important role in the occurrence,development and evolution of colorectal cancer(CRC).Bromodomain and extraterminal domain(BET)inhibitors can decrease the function...; 关键词：BROMODOMAIN Bromodomain and extraterminal domain inhibitor Colorectal cancer JAB-8263 MYC p21

灰葡萄孢Bromodomain转录因子家族成员鉴定及表达分析被引量：2: 《河北农业大学学报》2022年第6期94-101,共8页邓思琪李白马宇馨曹宏哲邢继红张康; 国家自然科学基金(31972217;32072369);河北省中央引导地方科技发展基金(206Z6501G;216Z6502G)。; 为了解灰葡萄孢Bromodomain转录因子家族成员的功能,本研究利用生物信息学方法对灰葡萄孢Bromodomain转录因子家族成员进行理化性质、染色体定位、系统发育、基因结构、保守结构域以及分生孢子发育时期及侵染时期的表达规律分析;并利用q...; 关键词：灰葡萄孢 BROMODOMAIN 转录因子基因表达

Discovery of CECR2 Bromodomain Inhibitors with High Selectivities over BPTF Bromodomain: 《Chinese Journal of Chemistry》2022年第17期2072-2080,共9页Haibo Lu Shijia Zu Zhe Duan Yueyao Feng Jie Wang Jingyi Ma Qi Li Dongying Chen Bo Li Kaixian Chen Cheng Luo Jin Lin Tian Lu Hua Lin; the Science and Technology Commission of Shanghai Municipality(Y811298033 to Q.L.,and 19XD1404700 to C.L.);the scientific research innovation program“Xiyuanjiang River Scholarship”of the College of Life Sciences,Fujian Normal University;the State Key Laboratory of Drug Research(SIMM2105KF-07toH.L.);Fujian Provincial Natural Science Foundation(2021J01203 to H.L.);the Natural Science Foundation of Fujian Province(2019J05073 to J.L.);the Joint Funds forthe Innovation of Science and Technology of Fujian Province(2018Y9071 to J.L.).; Cat's eye syndrome chromosome candidate 2 bromodomain(CECR2 BRD)and Bromodomain PHD transcription factor bromodomain(BPTF BRD)are the same subfamily proteins,both of which are highly conserved in sequence and binding ...; 关键词：CECR2 bromodomain BPTF bromodomain INHIBITORS Structure-activity relationships chemical probe

BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis被引量：1: 《Genes & Diseases》2022年第4期1062-1073,共12页Xiaorong Wang Mengmeng Sang Shengnan Gong Zhichuan Chen Xi Zhao Guishuan Wang Zhiran Li Yingying Huang Shitao Chen Gangcai Xie Enkui Duan Fei Sun; This study was supported by the National Key Research and Development Program of China (No. 2018YFC1003500);the National Natural Science Foundation of China (No. 81901528).; As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice ...; 关键词：Chromatin conformation JQ1 scRNA-seq Spermatid development SPERMATOGENESIS

BAP1 loss augments sensitivity to BET inhibitors in cancer cells: 《Acta Pharmacologica Sinica》2022年第7期1803-1815,共13页Yu-yan Xu Zhong-lu Ren Xiao-lian Liu Gui-ming Zhang Si-si Huang Wen-hui Shi Lin-xuan Ye Xin Luo Shu-wen Liu Yi-lei Li Le Yu; This work was supported by the National Natural Science Foundation of China(No.81973357);Guangdong Basic and Applied Basic Research Foundation(No.2020A1515010027);Wu Jieping Medical Foundation(No.320.6750.2020-10-120);Bethune Charitable Foundation Research Program(B-19-H-20200622).; The tumor suppressor gene BAP1 encodes a widely expressed deubiquitinase for histone H2A.Both hereditary and acquired mutations are associated with multiple cancer types,including cutaneous melanoma(CM),uveal melanoma...; 关键词：BRCA1-associated protein 1 bromodomain extraterminal inhibitors clear cell renal cell carcinoma cutaneous melanoma individualized therapy uveal melanoma

Bromodomain and extra-terminal inhibitors emerge as potential therapeutic avenues for gastrointestinal cancers: 《World Journal of Gastrointestinal Oncology》2022年第1期75-89,共15页Hui-Yan Sun Song-Tao Du Ya-Yun Li Guang-Tong Deng Fu-Rong Zeng; Fellowship of the China Postdoctoral Science Foundation,No.2020M682594,and No.2021T140748.; Gastrointestinal(GI)cancers,including colorectal cancer,pancreatic cancer,liver cancer and gastric cancer,are severe social burdens due to high incidence and mortality rates.Bromodomain and extra-terminal(BET)proteins...; 关键词：Gastrointestinal cancer Bromodomain and extra-terminal proteins Bromodomain and extra-terminal inhibitors Acetylated lysines

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