TMPRSS2

作品数：79被引量：124H指数：6
导出分析报告
相关领域：医药卫生农业科学更多>>
相关作者：高新戴美洁陶晶孙忠全李辽源更多>>
相关机构：中山大学附属第三医院复旦大学温州医学院附属第一医院复旦大学附属肿瘤医院更多>>
相关期刊：更多>>
相关基金：国家自然科学基金桂林市科学研究与技术开发项目北京市自然科学基金浙江省医药卫生科学研究基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-10
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
基于细胞的TMPRSS2抑制剂高通量筛选模型建立与应用
《药学学报》2024年第12期3273-3281,共9页尤宝庆 周雯雯 李妍 张晶 司书毅 
中国医学科学院医学与健康科技创新工程重大协同创新项目(2021-I2M-1-054)。
跨膜丝氨酸蛋白酶2 (transmembrane serine protease 2,TMPRSS2)是人体中广泛存在的细胞表面蛋白,参与严重急性呼吸综合征冠状病毒2 (severe acute respiratory syndrome coronavirus 2,SARS-CoV-2)等多种病毒的感染和前列腺癌细胞侵袭...
关键词：严重急性呼吸综合征冠状病毒2 跨膜丝氨酸蛋白酶2 高通量筛选模型 表面等离子共振 细胞-细胞融合 
High-resolution crystal structure of human coronavirus HKU1 receptor binding domain bound to TMPRSS2 receptor
《hLife》2024年第12期653-657,共5页Wei Wang Jiayu Guan Minjie Ren Zehou Li Weiwei Ji Rong Chen Ying Xu Shuijun Zhang 
supported by the Jiangsu Agriculture Science and Technology Innovation Fund(No.CX(23)3074 to S.Z.);the National Natural Science Foundation of China(No.32100128 to Y.X.,32170158 and 32000659 to S.Z.);the Natural Science Foundation of Jiangsu Province(Nos.BK20240087 and BK20200545 to S.Z.,BK20200553 to Y.X.,BK20241578 to W.J.);the Fundamental Research Funds for the Central Universities(No.KYRC2021007,KJJQ2024008,and KJQN202150 to S.Z.,KYQN2022013 to Y.X.);China Postdoctoral Science Foundation(No.2024M751428 to W.J.);the High-level personnel project of Jiangsu Province(No.JSSCBS20210290 to Y.X.),。
Coronaviruses pose serious threats to global public health.Severe acute respiratory syndrome coronavirus(SARS-CoV),Middle East respiratory syndrome coronavirus(MERS-CoV),and SARS-CoV-2 have resulted in large outbreaks...
关键词：RESPIRATORY MORTALITY acute 
Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2
《Cell Research》2024年第7期526-529,共4页Lingyun Xia Yuanyuan Zhang Qiang Zhou 
the National Natural Science Foundation of China(82241081);the Key Regional Research and Development Program(2023CSJZN0600);Ministry of Science and Technology of China,and the Hangzhou agricultural and social development scientific research project(202204B14).
Dear Editor,Human coronaviruses are pathogens capable of causing respiratory illnesses in humans,with seven identified species,1 three of which have caused epidemics or global pandemics in the past two decades,namely,...
关键词：TMPRSS2 ACUTE INVASION 
新型冠状病毒相关眼部疾病的研究进展
《国际眼科杂志》2024年第6期921-924,共4页於莹 李志坚 
2019年新型冠状病毒肺炎(COVID-19)自爆发以来已在短时间内呈现出全球大流行状态,新型冠状病毒(SARS-CoV-2)的多种变异株具有高度传染性和致病性。SARS-CoV-2可能通过血管紧张素转化酶2(ACE2)和跨膜丝氨酸蛋白酶2(TMPRSS2)的介导感染组...
关键词：新型冠状病毒(SARS-CoV-2) 血管紧张素转化酶2(ACE2) 跨膜丝氨酸蛋白酶2(TMPRSS2) 眼部疾病 
TMPRSS2 Polymorphism and Its Correlation with SARS-CoV-2 Susceptibility - A Secondary Publication
《Journal of Clinical and Nursing Research》2024年第5期329-335,共7页Saleem Awan Anum Siraj Amber Khan Arifa Anwar Muhammad Naeem Kiani Saira Yahya 
supported by grants from the Shaheed Zulfikar Ali Bhutto Institute of Science and Technology(SZABIST)University,Karachi,Pakistan.
Background:Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virus affected more people than SARS-CoV-1 and related coronaviruses.Human genetic factors,besides respiratory droplets and direct exposure to the ...
关键词：TMPRSS2 SARS-CoV-2 ACE2 Gene COVID-19 Expression 
Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1
《Chinese Chemical Letters》2024年第5期201-206,共6页Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang Wang Danqing Song 
supported by the National Natural Science Foundation of China(No.81974494);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-070).
Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalab...
关键词：ALOPERINE SARS-CoV-2 TMPRSS2 SR-B1 Synthesis 
TMPRSS2-ERG融合基因在前列腺癌中的研究进展
《中国现代医生》2024年第9期110-113,共4页钟远峰 王兴枝子 黄敏玉 
广西高校中青年教师科研基础能力提升项目(2021KY0561);右江民族医学院附属医院高层次人才科研项目(Y202011716)。
在前列腺癌中,跨膜丝氨酸蛋白酶2(transmembrane serine protease 2,TMPRSS2)-E26转化特异性相关基因[E26 transformation-specific(ETS)-related gene,ERG]融合基因由雄激素调控基因TMPRSS2(染色体21q22.2)与ERG(染色体21q22.3)融合形...
关键词：前列腺癌 跨膜丝氨酸蛋白酶2 E26转化特异性相关基因 融合基因 作用机制 临床治疗 
不同母核结构苦豆碱衍生物合成及其抗冠状病毒活性研究被引量：1
《药学学报》2024年第2期404-412,共9页孟润泽 公玥 施宇龙 王坤 彭宗根 宋丹青 
国家自然科学基金(81974494);中国医学科学院医学与健康科技创新工程资助项目(2021-I2M-1-048)。
本研究设计合成了不同母核结构的12个全新苦豆碱衍生物,其中十元大环骨架苦豆碱衍生物3通过季铵盐γ-H的霍夫曼消除后扩环获得,结构经X-单晶确证。进而采用CCK-8法评价了目标物对抗人类β-冠状病毒HCoV-OC43的活性。结果显示,季铵盐苦豆...
关键词：季铵盐苦豆碱 新型冠状病毒 十元环苦豆碱 TMPRSS2 SR-B1 
NSP16 promotes the expression of TMPRSS2 to enhance SARS-CoV-2 cell entry
《Genes & Diseases》2023年第3期723-726,共4页Tianyu Han Jiapeng Lei Yang Liu Yanan Wang Wenze Xun Qifan Hu Qi Peng Wei Zhang 
supported by Clinical Research Cultivation Project of First Affiliated Hospital of Nanchang University(China)(No.YFYLCYJPY202001).
Since the end of 2019,COVID-19 has caused worldwide pandemic.SARS-CoV-2,the culprit of this epidemic,binds to the host receptor Angiotensin converting enzyme 2(ACE2)using spike(S)protein for cell entry.Recent studies ...
关键词：ACE2 NSP1 ORGANS 
TMPRSS2 and SARS-CoV-2 SPIKE interaction assay for uHTS
《Journal of Molecular Cell Biology》2023年第3期32-43,共12页Danielle Cicka Qiankun Niu Min Qui Kun Qian Eric Miller Dacheng Fan Xiulei Mo Andrey AIvanov Stefan GSarafianos Yuhong Du Haian Fu 
supported in part by the Emory School of Medicine COVID Catalyst-I3 award(H.F.and S.G.S.);the NCI Emory Lung Cancer SPORE(P50CA217691)Career Enhancement Program(A.A.I.);Emory Initiative on Biological Discovery through Chemical Innovation(A.A.I.);R01AI167356(S.G.S.).
SARS-CoV-2,the coronavirus that causes the disease COVID-19,has claimed millions of lives over the past 2 years.This demands rapid development of effective therapeutic agents that target various phases of the viral re...
关键词：SARS-CoV-2 COVID-19 protein-protein interaction TMPRSS2 SPIKE high-throughput screening TR-FRET 
全选清除导出
共8页<12345678>
检索报告 对象比较 聚类工具 使用帮助 返回顶部