新型冠状病毒相关眼部疾病的研究进展  

Research progress on ocular diseases associated with SARS-CoV-2

作　　者：於莹 李志坚[1] Yu Ying;Li Zhijian(Eye Hospital,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,Heilongjiang Province,China)

机构地区：[1]哈尔滨医科大学附属第一医院眼科医院,黑龙江省哈尔滨市150001

出　　处：《国际眼科杂志》2024年第6期921-924,共4页International Eye Science

摘　　要：2019年新型冠状病毒肺炎(COVID-19)自爆发以来已在短时间内呈现出全球大流行状态,新型冠状病毒(SARS-CoV-2)的多种变异株具有高度传染性和致病性。SARS-CoV-2可能通过血管紧张素转化酶2(ACE2)和跨膜丝氨酸蛋白酶2(TMPRSS2)的介导感染组织细胞从而引发不同疾病。呼吸道、心血管、胃肠道系统的临床疾病较为常见;也有大部分患者以眼部症状为主诉就诊。相较于严重的全身系统疾病,眼部相关症状很容易被忽视。文章通过对SARS-CoV-2相关多种眼部疾病的发病机制和相关病例进行综述,旨在增强临床医师对SARS-CoV-2相关眼病的重视,避免延误病情,造成视力的不可逆损失,并为眼部疾病的预防和治疗提供新思路。The corona virus disease 2019(COVID-19)in 2019 has shown a global pandemic status in a short time since its outbreak,and many variants of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)were highly infectious and pathogenic.SARS-CoV-2 may infect tissue cells through the mediation of angiotensin-converting enzyme-2(ACE2)and transmembrane serine protease 2(TMPRSS2),leading to different diseases.Clinically,respiratory,cardiovascular,and gastrointestinal systems diseases are relatively common;many patients also seek medical attention based on eye symptoms as their main complaint.Compared with severe systemic diseases,eye-related symptoms are easily overlooked.This article reviews the pathogenesis and cases of various eye diseases related to SARS-CoV-2,aiming to enhance clinicians’attention to SARS-CoV-2-related eye diseases,avoid delaying the disease and causing irreversible loss of vision,and provide new ideas for the prevention and treatment of eye diseases.

关 键 词：新型冠状病毒(SARS-CoV-2) 血管紧张素转化酶2(ACE2) 跨膜丝氨酸蛋白酶2(TMPRSS2) 眼部疾病 

分 类 号：R771.3[医药卫生—眼科]