ALOPERINE

作品数：5被引量：17H指数：3
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相关领域：医药卫生更多>>
相关机构：内蒙古医科大学更多>>
相关期刊：《Chinese Journal of Natural Medicines》《中西医结合心血管病电子杂志》《Journal of Chinese Pharmaceutical Sciences》《Chinese Chemical Letters》更多>>
相关基金：国家自然科学基金更多>>
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Five quinolizidine alkaloids with anti-tobacco mosaic virus activities from two species of Sophora
《Chinese Chemical Letters》2024年第6期380-384,共5页Ji Zhang Tong Zhang Qiao An Peng Zhang Cai-Yan Tian Chun-Mao Yuan Ping Yi Zhan-Xing Hu Xiao-Jiang Hao 
financially supported by the National Natural Science Foundation of China(Nos.32160103 and U1812403);the Science and Technology Department of Guizhou Province(Nos.QKH ZC-[2021]-YB181,QKH CXTD-[2022]-007 and QKH ZYD-[2022]-4015);Guizhou Provincial Engineering Research Center for Natural Drugs。
Three novel matrine-type alkaloids(1-3)and two unprecedented aloperine-type alkaloids(4 and 5)were isolated from the root of Sophora tonkinensis and the seeds of Sophora alopecuroides respectively.Notably,compound 1 p...
关键词：Matrine-type alkaloids Aloperine-type alkaloids Sophora tonkinensis Sophora alopecuroides Anti-tobacco mosaic virus 
Chemical construction and anti-HCoV-OC43 evaluation of novel 10,12-disubstituted aloperine derivatives as dual cofactor inhibitors of TMPRSS2 and SR-B1
《Chinese Chemical Letters》2024年第5期201-206,共6页Yulong Shi Fenbei Chen Mengyuan Wu Xin Zhang Runze Meng Kun Wang Yan Wang Yuheng Mei Qionglu Duan Yinghong Li Rongmei Gao Yuhuan Li Hongbin Deng Jiandong Jiang Yanxiang Wang Danqing Song 
supported by the National Natural Science Foundation of China(No.81974494);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-070).
Thirty-one new 10,12-disubstituted aloperine derivatives were subtly constructed through a selective oxidation on the 10-α-C-H induced by sulfonyl and a nucleophilic substitution with the stereoselectivity and scalab...
关键词：ALOPERINE SARS-CoV-2 TMPRSS2 SR-B1 Synthesis 
The anti-neoplastic activities of aloperine in HeLa cervical cancer cells are associated with inhibition of the IL-6-JAK1-STAT3 feedback loop被引量：7
《Chinese Journal of Natural Medicines》2021年第11期815-824,共10页CHEN Yao-Dong CAI Fang-Yu MAO Yu-Ze YANG Yong-Sheng XU Kun LIU Xiao-Fang FAN Wen-Wen CHEN Wu JIANG Feng-Qi ZHANG Hui 
This work was supported by the National Natural Science Foundation of China(No.82001850);Shanxi Basic Application Research(No.201901D211491);the Scientific Research Project of Shanxi Health Commission(No.2019038);the Doctoral Research Project of Shanxi Medical University(No.XD1901);the Doctoral Research Project of Shanxi Province(No.SD1901).
Cervical cancer(CC)is recognized as the most common neoplasm in the female reproductive system worldwide.The lack of chemotherapeutic agents with outstanding effectiveness and safety severely compromises the anti-cipa...
关键词：Cervical cancer CHEMOTHERAPY ALOPERINE Epithelial-mesenchymal transition IL-6-JAK1-STAT3 feedback loop 
中药单体苦参碱(Aloperine)对肺动脉高压疾病的治疗机制被引量：6
《中西医结合心血管病电子杂志》2020年第36期35-35,45,共2页格根图雅 徐磊 
苦参碱(Aloperine)是一种从中草药中提取出的喹喔啉生物碱,近年来基础研究和临床研究表明,Aloperine通过体外和体内诱导细胞凋亡和细胞周期阻滞而发挥抗肿瘤作用,并同时具有抗纤维化、抗炎等多种作用,均可有效控制肺动脉高压(PH)的发展...
关键词：苦参碱 肺动脉高压 高血压 肺动脉平滑肌细胞 
Development and Validation of a Novel Reverse Phase HPLC for Determination of Aloperine in Aloperine Tablets被引量：4
《Journal of Chinese Pharmaceutical Sciences》2003年第4期211-214,共4页WANGHua ZHENGLi WANGZhan ZHANGYong-qiang] WUFeng-lan 
Aim To develop a reverse phase HPLC method for the determination of aloperine, an alkaloid that is newly extracted from Sophora alopecuraides and has shown wide pharmacological effects including antibacterial and...
关键词：ALOPERINE aloperine tablets RP HPLC 
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