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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future
《Neural Regeneration Research》2025年第4期946-959,共14页Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia Huo Haiwei Xu 
supported by the National Natural Science Foundation of China,No.31930068;National Key Research and Development Program of China,Nos.2018YFA0107302 and 2021YFA1101203(all to HX).
Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased states.In lower vertebrates like zebrafish,these cells assume responsibi...
关键词：cell fusion chemical small-molecules EPIGENETIC extracellular matrix immune metabolic MICE Müller glia neurodegenerative diseases REPROGRAMMING retina regeneration 
Tailoring small-molecule acceptors through asymmetric side-chain substitution for efficient organic solar cells
《Science China Materials》2025年第3期860-867,共8页Lan Xie Dingding Qiu Xianghao Zeng Chung Hang Kwok Yan Wang Jia Yao Kan Ding Lu Chen Jicheng Yi Harald Ade Zhixiang Wei Wai-Yeung Wong He Yan Han Yu 
the Hong Kong Research Grants Council(GRF project,16303024,16310824);the support from the National Key Research and Development Program of China(2019YFA0705900)funded by Ministry of Science and Technology of China;Basic and Applied Research Major Program of Guangdong Province(2019B030302007);National Natural Science Foundation of China(NSFC,22075057);Shen Zhen Technology and Innovation Commission through Shenzhen Fundamental Research Program(JCYJ20200109140801751);Hong Kong Research Grants Council(research fellow scheme RFS2021-6S05,RIF project R6021-18,CRF project C6023-19G,GRF project 16310019,16310020,16309221,16309822);Hong Kong Innovation and Technology Commission(ITCCNERC14SC01);Foshan-HKUST(FSUST19-CAT0202);Zhongshan Municipal Bureau of Science and Technology(ZSST20SC02);Guangdong-Hong Kong-Macao Joint Laboratory(2023B1212120003);Tencent Xplorer Prize;the financial support from the RGC Senior Research Fellowship Scheme(SRFS2021-5S01).
Side chain engineering of small-molecule acceptors(SMAs)is a promising strategy for improving device efficiency in organic solar cells(OSCs).This study investigates the parent SMAs of BT-BO and BT-TBO,along with the n...
关键词：organic solar cells side chain engineering active layer asymmetric acceptors thiophene side chains 
Potential role and therapeutic implications of glutathione peroxidase 4 in the treatment of Alzheimer's disease
《Neural Regeneration Research》2025年第3期613-631,共19页Yanxin Shen Guimei Zhang Chunxiao Wei Panpan Zhao Yongchun Wang Mingxi Li Li Sun 
supported by the National Natural Science Foundation of China,No.82071442 (to LS);a grant from the Jilin Provincial Department of Finance,No.JLSWSRCZX2021-004 (to LS)。
Alzheimer's disease is an age-related neurodegenerative disorder with a complex and incompletely understood pathogenesis. Despite extensive research, a cure for Alzheimer's disease has not yet been found. Oxidative st...
关键词：apoptosis ferroptosis inflammation lipid peroxidation natural plant products neurodegenerative disorder NEUROPROTECTION oxidative stress small-molecule drugs 
Unprecedented short-circuit current density and efficiency of vacuum-deposited organic solar cells based on 8H-thieno[2,3:4,5]thieno[3,2-b]thieno[2,3-d]pyrrole
《Science Bulletin》2025年第6期897-904,共8页Bin-Wen Chen Ming-Wei An Kang Wang Sang Young Jeong Xu Wang Zhen-Lin Qiu Kun Cao Shan-Yu Zheng Lu Wang Han Young Woo Da-Qin Yun Lin-Long Deng Su-Yuan Xie Lan-Sun Zheng 
supported by the National Natural Science Foundation of China(92361303,92061204,and 52203228);the Natural Science Foundation of Guangdong Province of China(2023A1515011916);the China Postdoctoral Science Foundation(2022M712658);Han Young Woo acknowledges the financial support from the National Research Foundation of Korea(2019R1A6A1A11044070,and RS-2024-00334832).
Despite the many advantages for industrial mass production,vacuum-deposited organic solar cells(OSCs)suffer from low efficiency,primarily due to the limited molecular library of small-molecule donor and acceptor mater...
关键词：Organic solar cells Vacuum deposition Small-molecule donor D-A-A configuration 8H-Thieno[2 3:4 5]thieno[3 2-b]thieno[2 3-d]pyrrole 
Stretchable All-Small-Molecule Organic Solar Cells Enabled by Polymer Elastomer Confinement
《Chinese Journal of Polymer Science》2025年第2期271-277,共7页Chen-Yi Zhang Yu-Qiang Liu Hong-Xiang Li Xin-Yue Cui Zheng-Dong Wei Yue-Heng Liu Ming-Hua Li An-Dong Zhang Pei Cheng Zhi-Shan Bo 
financially supported by the National Natural Science Foundation of China(Nos.52303239 and 51933001);Natural Science Foundation of Shandong Province(Nos.ZR2022QB141 and 2023HWYQ-087).
Intrinsic stretchability is a promising attribute of polymer organic solar cells(OSCs).However,rigid molecular blocks typically exhibit poor tensile properties,rendering polymers vulnerable to mechanical stress.In thi...
关键词：All-small-molecule Organic solar cells ELASTOMER Stretchability FLEXIBILITY 
Research progress of small-molecule natural medicines for the treatment of ischemic stroke
《Chinese Journal of Natural Medicines》2025年第1期21-30,共10页Kui Liu Ling Wang Tao Pang 
supported by the National Natural Science Foundation of China(Nos.82174010 and 81973512)。
Stroke is the second leading cause of disability and mortality worldwide,imposing a substantial socioeconomic burden on individuals and healthcare systems.Annually,approximately 14 million people experience stroke,wit...
关键词：Natural medicines Small molecule Ischemic stroke ANTIOXIDANTS NEUROINFLAMMATION 
Digitoxose as powerful glycosyls for building multifarious glycoconjugates of natural products and un-natural products
《Synthetic and Systems Biotechnology》2024年第4期701-712,共12页Kemeng Li Zhengyan Guo Liping Bai 
supported by grants from National Key Research and Development Program of China(2018YFA0902000);National Natural Science Foundation of China(82173721);CAMS Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-029).
Digitoxose,a significant 2,6-dideoxyhexose found in nature,exists in many small-molecule natural products.These digitoxose-containing natural products can be divided into steroids,macrolides,macrolactams,anthracycline...
关键词：Digitoxose BIOSYNTHESIS Small-molecule natural products Digitoxose glycosylation 
Expert Consensus on the Clinical Application of Oral Small-molecule Antiviral Drugs Against COVID-19
《Infectious Diseases & Immunity》2024年第4期158-169,共12页无 Nanshan Zhong Guiqiang Wang 
Emergency Key Program of Guangzhou Laboratory(EKPG21-06);the Macao Science and Technology Development Fund(0022/2021/A1);the Young Top Talent of Science and Technology Innovation Department of Guangdong Province(2021TQ060189);National Administration of Traditional Chinese Medicine’s Interdisciplinary Innovation Team Project(ZYYCXTU-D-202201).
Although COVID‑19 no longer constitutes a“public health emergency of international concern”,which still has being spreading around the world at a low level.Small molecule drugs are the main antiviral treatment for n...
关键词：Coronavirus infections Antiviral therapy Small molecule drugs Early stage Expert consensus 
Development of a multi-level pH-responsive lipid nanoplatform for efficient co-delivery of si RNA and small-molecule drugs in tumor treatment
《Chinese Chemical Letters》2024年第12期265-272,共8页Yunjie Dang Yanru Feng Xiao Chen Chaoxing He Shujie Wei Dingyang Liu Jinlong Qi Huaxing Zhang Shaokun Yang Zhiyun Niu Bai Xiang 
supported by the grants from the National Natural Science Foundation of China(Nos.81973251 and 81302725);Hebei Province Funding Project for Introduced Overseas Personnel(Nos.C20230351 and C20220345);Key Research and Development Program of Hebei Province(No.22372701D);Hebei Province Natural Science Fund(No.H2020206610);Hebei Provincial Health Commission Government-Funded Clinical Medicine Talent Program(No.ZF2024048);Hebei Medical University Undergraduate Innovative Experiment Program(No.USIP2023008)。
The combination of nucleic acid and small-molecule drugs in tumor treatment holds significant promise;however,the precise delivery and controlled release of drugs within the cytoplasm encounter substantial obstacles,i...
关键词：Cyclic peptides siRNA Liposomal platform Multi-level pH-responsive CO-DELIVERY 
Reaction-based small-molecule fluorescent probes for endoplasmic reticulum-and mitochondria-targeted biosensing and bioimaging
《Science China Materials》2024年第11期3491-3530,共40页Abdul Hadi Mehmood Faiz Ullah Baoli Dong Hong Liu 
the financial support from the China National Key R&D Program(2023YFB3210400);Key R&D Program of Shandong Province(2021CXGC010603);the National Natural Science Foundation of China(NSFC)(22377032);the Natural Science Foundation of Shandong Province(ZR2021MB022)。
Fluorescent probes have revolutionized modern biological research by making it possible to observe and measure an extensive range of cellular and subcellular processes.Among the subcellular compartments,the endoplasmi...
关键词：endoplasmic reticulum mitochondria fluorescent probe fluorescence imaging 
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