云南高校图书馆联盟文献共享服务平台- MISFOLDING

MISFOLDING: 作品数：12被引量：5H指数：1; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：柏鸣柯莎朱笠江轶李辉更多>>; 相关机构：中国科学院更多>>; 相关期刊：《Open Journal of Biophysics》《Journal of Pharmacy and Pharmacology》《World Journal of Neurology》《Chinese Physics B》更多>>; 相关基金：国家重点基础研究发展计划更多>>

Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity: 《Neural Regeneration Research》2024年第10期2095-2096,共2页Alessandro Cembran Pedro Fernandez-Funez; supported by the NIH grant7R21 NS09662 7-02 to PFF;the Winston and Maxine Wallin Neuroscience Discovery Fund award CON000000083928 to PFF and AC。; The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of the...; 关键词：FOLDING INTRINSIC DYNAMICS

Unraveling the molecular mechanism of prion disease:Insights fromα2 area mutations in human prion protein: 《Chinese Physics B》2023年第12期657-665,共9页谈荣日夏奎寻大毛宗文军余幼胜; Project supported by the National Natural Science Foundation of China (Grant Nos.52073128,12164002,and 11964012);the Foundation of Educational Committee of Jiangxi Province of China (Grant No.GJJ211112);the Fund for Distinguished Young Scholars of Jiangxi Science&Technology Normal University (Grant No.2015QNBJRC002)。; Prion diseases are a class of fatal neurodegenerative diseases caused by misfolded prion proteins.The main reason is that pathogenic prion protein has a strong tendency to aggregate,which easily induces the damage to ...; 关键词：prion protein MUTATIONS MISFOLDING molecular dynamics simulations

Alexander disease:the road ahead被引量：1: 《Neural Regeneration Research》2023年第10期2156-2160,共5页María A.Pajares Elena Hernández-Gerez Milos Pekny Dolores Pérez-Sala; Work at the authors’laboratories is supported by grants from"la Caixa"Foundation;Grant Agreement LCF/PR/HR21/52410002;EJP RD COFUND-EJP N°825575"Alexander"to DPS and MP;Agencia Estatal de Investigacion,MICINN and ERDF Grant No.RTI2018-097624-B-I00 and PID2021-126827OB-I00 to DPS;grants from the Swedish Research Council(2017-02255);ALF Gothenburg(146051);The Swedish Society for Medical Research,Hj?rnfonden,S?derberg’s Foundations,Hagstr?mer’s Foundation Millennium,Ami?v’s Foundation,E.Jacobson’s Donation Fund,the Swedish Stroke Foundation,NanoNet COST Action(BM1002),EU FP 7 Program TargetBraln(279017)to MP。; Alexander disease is a rare neurodegenerative disorder caused by mutations in the glial fibrillary acidic protein,a type III intermediate filament protein expressed in astrocytes.Both early(infantile or juvenile)and a...; 关键词：ASTROCYTES endoplasmic reticulum stress glial fibrillary acidic protein mutants metabolism misassembly MISFOLDING NEURODEGENERATION oxidative stress posttranslational modifications unfolded protein response

Adenosine A1 receptor ligands bind toα-synuclein:implications forα-synuclein misfolding andα-synucleinopathy in Parkinson’s disease: 《Translational Neurodegeneration》2022年第1期809-834,共26页Elisabet Jakova Mohamed Taha Moutaoufik Jeremy S.Lee Mohan Babu Francisco S.Cayabyab; the Animal Review and Ethics Board(AREB)of the University of Saskatchewan(Animal Use Protocol#20070090).; Background:Accumulatingα-synuclein(α-syn)aggregates in neurons and glial cells are the staples of many synucleinopathy disorders,such as Parkinson’s disease(PD).Since brain adenosine becomes greatly elevated in age...; 关键词：Alpha-synucleinopathy Adenosine A1 receptor N6-cyclopentyladenosine 8-cyclopentyl-1 3-dipropylxanthine 1-aminoindan 2-aminoindan Neuroprotection Neurodegeneration Protein misfolding

Effects of Klebsiella pneumoniae on Toll-Like Receptor-Dependent Endoplasmic Reticulum Stress-Related Signaling Pathways and Gene Expression and Promotes HLA-B27 Misfolding: 《Journal of Pharmacy and Pharmacology》2016年第12期667-678,共12页Wen-Jen Cheng Yu-Ling Wei James Cheng-Chung Wei Chia-Wei Lin Hui-Yin Lu Yu-Pu Hsia Pei-Jane Tsai Ying-Chun Lai Yu-Liang Kuo Ming-Shiou Jan; Klebsiella has been considered as initiator of AS （ankylosing spondylitis） for nearly four decades. This study aimed to demonstrate that Klebsiella triggers ERS （endoplasmic reticulum stress） and HLA-B27 heavy cha...; 关键词：Klebsiella pneumoniae endoplasmic reticulum stress ankyiosing spondylitis Toll-like receptor 9 MYD88 HLA-B27misfolding.

Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response: 《World Journal of Virology》2015年第3期188-197,共10页Raymond Bujdoso Matthias Landgraf Walker S Jackson Alana M Thackray; Supported by The NC3Rs,No.NC/K000462/1(in part); Protein misfolding neurodegenerative diseases arisethrough neurotoxicity induced by aggregation of host proteins. These conditions include Alzheimer's disease, Huntington's disease, Parkinson's disease, motor neuron d...; 关键词：NEURODEGENERATIVE disease Protein MISFOLDING PRION Transmissible Cell cycle DNA repair CHROMATIN PrP transgenic DROSOPHILA

Human Prion Protein Conformational Changes Susceptibility: A Molecular Dynamics Simulation Study: 《Open Journal of Biophysics》2014年第4期169-175,共7页Laura Alejandra Mandujano-Rosas Daniel Osorio-González Pedro Guillermo Reyes-Romero Jorge Mulia-Rodríguez; Prion proteins are related to the development of incurable and invariably fatal neurodegenerative diseases in humans and animals. The pathogenicity involves the conversion of the host-encoded-alpha rich isoform of pri...; 关键词：PRION PROTEIN MISFOLDING SUSCEPTIBILITY MOLECULAR Dynamics Simulation

Protein seeding in Alzheimer's disease and Parkinson's disease: Similarities and differences: 《World Journal of Neurology》2014年第4期23-35,共13页Tarek Ibrahim JoAnne McLaurin; Supported by In part by CIHR MOP#102467(Mc Laurin J);Cryptic Rite Charitable Foundation(Mc Laurin J); Neurodegenerative pathology can be seeded by introduction of misfolded proteins and peptides into the nervous system. Models of Alzheimer's disease(AD) and Parkinson's disease(PD) have both demonstrated susceptibility...; 关键词：Alzheimer’s DISEASE Parkinson’s DISEASE Prionoid SEEDING Propagation PROTEIN MISFOLDING

Heat Shock Protein 40 (Hsp40) and Hsp70 Protein Expression in Oral Squamous Cell Carcinoma (OSCC)被引量：1: 《Journal of Cancer Therapy》2013年第3期734-741,共8页Adi Prayitno Elyana Asnar Okid Parama Astirin Dinar Rosmala Suhartono Taat Putra; Introduction: As a chaperone, heat shock protein acts as central integrators of protein homeostasis in cell. The form of these functions is to help setting up a complex protein molecular fold (folded protein) in many ...; 关键词：CHAPERONE Hsp40 HSP70 MISFOLDING OSCC

Apolipoproteins and amyloid fibril formation in atherosclerosis被引量：2: 《Protein & Cell》2011年第2期116-127,共12页Chai Lean Teoh Michael D.W.Griffin Geoffrey J.Howlett; Amyloid fibrils arise from the aggregation of misfolded proteins into highly-ordered structures.The accumulation of these fibrils along with some non-fibrillar constituents within amyloid plaques is associated with th...; 关键词：MISFOLDING APOLIPOPROTEINS amyloid fibril ATHEROSCLEROSIS

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

MISFOLDING

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

MISFOLDING

检索结果分析

下载全文

用户登录

高级检索检索式检索