STEROL

作品数：64被引量：241H指数：9
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Regulatory Mechanism of Xiaozheng Tongluo Method on Hepatic Lipid Metabolism in ApoE^(-/-) Mice:Insights from the Sterol Regulatory Element-binding Protein-2/3-hydroxy-3-methylglutaryl Coenzyme A Reductase/Low-density Lipoprotein Receptor Signaling Pathwa
《World Journal of Traditional Chinese Medicine》2024年第3期363-369,共7页Xin Zhang Jian-Li Ge Kun Su Jian-Ming He Min-Mei Zhang Jing Zhang Yun-Long Ma Yun-Chao Sun Xin-Qiang Chu 
supported by the Science and Technology Support Program Project of the Hebei Provincial Department of Science and Technology (No. 19277753D);the Scientific Research Project of the Hebei Administration of TCM (No. 2019004, No. 2019066)
Objective: The objective of the study was to explore the regulatory mechanism of the Xiaozheng Tongluo method on lipid metabolism in liver tissue based on the sterol regulatory element-binding protein-2/(SREBP2)/3-hyd...
关键词：ApoE^(‑/‑)mice lipid metabolism liver sterol regulatory element‑binding protein‑2/3‑hydroxy‑3‑methylglutaryl coenzyme a reductase/low‑density lipoprotein receptor signaling pathway Xiaozheng Tongluo method 
OsFK1 encodes C-14 sterol reductase,which is involved in sterol biosynthesis and affects premature aging of leaves in rice
《The Crop Journal》2024年第4期1010-1021,共12页Ping Li Xia Zhang Wuzhong Yin Yang Shui Jie Zhang Nana Xu Dasong Bai Qingxiong Huang Yuanyuan Li Pan Qi Xing Li Qianlong Li Shihong Yang Guotao Yang Hong Chen Peng Qin Yungao Hu Youlin Peng 
supported by the National Natural Science Foundation of China(32001491,32360493);Natural Science Foundation of Sichuan Province(2022NSFSC0153,2022NSFSC1754,2023NSFSC1170);the Key Research and Development Program of Sichuan Province(2021YFYZ0016).
The enzyme C-14 sterol reductase is involved in biosynthesis of brassinosteroids(BR)and sterols,as well as plant development.OsFK1,a member of the sterol biosynthesis pathway located in the endoplasmic reticulum(ER),e...
关键词：Leaf development ROS Phytosterol biosynthesis RICE 
Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma
《World Journal of Hepatology》2024年第3期439-451,共13页Chang-Jiao Gan Yue Zheng Bin Yang Li-Min Cao 
Supported by the Tianjin Municipal Project of Science and Technology,No.21ZXGWSY00040;and the Tianjin Health Research Project,No.TJWJ2022QN043.
BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver cancer.However,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not clear....
关键词：Sterol O-acyltransferase 1 Hepatocellular carcinoma PROGNOSTIC IMMUNE 
The function of steroid terminal monooxygenase in cholesterol or phytosterol degradation by the Mycobacterium neoaurum NRRL B‑3805
《Systems Microbiology and Biomanufacturing》2023年第4期585-592,共8页Xuemei Li Rui Zhang Jianjiong Li Jinhui Feng Qiaqing Wu Dunming Zhu Yanhe Ma 
supported by the National Key R and D Program of China(NO.2019YFA0905300);National Natural Science Foundation of China(No.32171477);Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project(No.TSBICIP-KJGG-001 and TSBICIP-PTJJ-007).
Cholesterol and phytosterols can be served as the substrates for Actinobacteria to produce the precursors used in the synthesis of steroidal medicines.Cytochrome P450s from CYP125 and CYP142 families initiates the met...
关键词：Sterol degradation Mycobacterium neoaurum Steroid C26/C27 monooxygenase Cytochrome CYP125s and CYP142s 
Recent advances in research on natural product inhibitors of SREBPs
《Traditional Medicine Research》2022年第3期55-67,共13页Yi-Ping Zhang Jing Jin Ping Li Hua Yang Zu-Guo Zheng 
supported by the National Natural Science Foundation of China(81903871);Natural Science Foundation of Jiangsu Province(BK20190565);Fundamental Research Funds for the Central Universities(2632021ZD16).
Sterol regulatory element-binding proteins(SREBPs)are a class of cholesterol-sensitive transcription factors that play important roles in lipid metabolism.Natural product inhibitors of SREBPs have been shown to inhibi...
关键词：sterol-regulatory element-binding protein lipid metabolism metabolic disease natural product traditional Chinese medicine 
CYP27A1 mutation in a case of cerebrotendinous xanthomatosis:A case report
《World Journal of Clinical Cases》2022年第18期6168-6174,共7页Zhao-Ran Li Yu-Ling Zhou Qi Jin Yin-Yin Xie Hong-Mei Meng 
BACKGROUND Cerebrotendinous xanthomatosis(CTX)is a rare autosomal recessive metabolic disease caused by mutations in CYP27 A1.It has a low incidence rate,insidious onset,and diverse clinical manifestations.It can be e...
关键词：Cerebrotendinous xanthomatosis CYP27A1 Sterol 27-hydroxylase c.380G> c.1563dup A Case report 
Identification of potential inhibitors for Sterol C-24 reductase of Leishmania donovani through virtual screening of natural compounds
《BIOCELL》2021年第6期1601-1610,共10页FAZLUR RAHMAN SHAMS TABREZ RAHAT ALI SAJJADUL KADIR AKAND MOHAMMED AALAIDAROUS MOHAMMED ALSAWEED BADER MOHAMMED ALSHEHRI SAEED BANAWAS ABDUR RUB ABDUL AZIZ BIN DUKHYIL 
Deanship of Scientific Research at Majmaah University,Al Majmaah,11952,Saudi Arabia for supporting this work under the Group Project No.RGP-2019-31.
Leishmaniasis is a vector-borne parasitic neglected tropical disease caused by a group of about 30 different species of the genus Leishmania.It is transmitted by the bite of female phlebotomies sand fly.Three main cli...
关键词：LEISHMANIA GINGEROL Sterol C-24 reductase Molecular docking ROS 
Self-assembly of metal-cholesterol oxidase hybrid nanostructures and application in bioconversion of steroids derivatives
《Frontiers of Chemical Science and Engineering》2021年第3期615-629,共15页Yu Xin Qiuyue Gao Yu Gu Mengyao Hao Guangming Fan Liang Zhang 
supported by the National Key Research and Development Program of China(Grant No.2018YFA0900304-300);the Natural Science Foundation of Jiangsu Province(Grant Nos.BK20160053 and BE2018055);the Priority Academic Program Development of Jiangsu Higher Education Institutions,111 Project(Grant No.111-2-06).
A cholesterol oxidase(COD)was hybridized with Ca^(2+),Zn^(2+),Al^(3+),Fe^(2+) and Mn^(2+).After precipitation with PO_(4)^(3-) at 4℃ for 72 h,the resulting pellets were freeze-dried.In scanning electron microscopy as...
关键词：cholesterol oxidase metal-enzyme hybridization nanostructures sterol derivatives bioconversion 
Mechanism of Cangfu Daotan pill in treating polycystic ovary syndrome based on network pharmacology被引量：1
《Journal of Hainan Medical University》2021年第12期26-31,共6页Pan-Wei Hu Jia Li Dan Liu Hong Yang 
Shanghai“Xinglin New Star”project[ZY(2018-2020)-RCPY-3012];Clinical study on improving the endometrial receptivity of patients with polycystic ovary syndrome by the method of invigorating the kidney,removing phlegm and promoting blood circulation(Project within budget of Shanghai university of traditional Chinese medicine);The construction project of Shanghai famous old traditional Chinese medicine experience research studio(No.SHGZS-2017026);Shanghai university of traditional Chinese medicine affiliated Shuguang hospital Siming fund(In-hospital project)
Objective:To explore the target and molecular mechanism of Cangfu Daotan pill in the treatment of polycystic ovary syndrome(PCOS)by network pharmacology.Methods:The main active components and corresponding targets of ...
关键词：Cangfu Daotan pill Polycystic ovary syndrome Network pharmacology STEROL FLAVONE 
First Isolation and Confirmation of Sterol Based on β-sitosterol Skeleton from the Leaves of Podocarpusnagi Planted in Fujian, Preliminary in vitro Anticancer Activity and the Crystal Structure
《Chinese Journal of Structural Chemistry》2021年第5期653-658,531,共7页YANG Yang YONG Jian-Ping OLAGOKE Zacchaeus Olatunde LU Can-Zhong 
financially supported by the National Natural Science Foundation of China(21875252);Self-created Area Project of Major Science Technology Innovation Platform of Xiamen(3502ZCQ20171002)。
The crystal of(24 R)-3β,5α-dihydroxy-24-ethyl-5α-cholestan-6-one(1) was isolated from the leaves of P.nagi planted in Fujian for the first time with the same skeleton as 26,27-dinorcholest-5-en-3-β-ol(2) andβ-sit...
关键词：Podocarpusnagi crystal structure STEROLS ISOLATION anticancer evaluation 
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