Comprehensive prognostic and immune analysis of sterol Oacyltransferase 1 in patients with hepatocellular carcinoma  

作　　者：Chang-Jiao Gan Yue Zheng Bin Yang Li-Min Cao 

机构地区：[1]Development Research Department,National Medical Products Administration Institute of Executive Development,Beijing 100071,China [2]School of Medicine,Nankai University Affiliated Third Center Hospital,Tianjin 300070,China [3]Tianjin Institute of Hepatobiliary Disease,The Third Central Hospital of Tianjin,Tianjin 300170,China [4]Department of Science and Technology,Tianjin Third Central Hospital,Tianjin 300170,China

出　　处：《World Journal of Hepatology》2024年第3期439-451,共13页世界肝病学杂志（英文版）（电子版）

基　　金：Supported by the Tianjin Municipal Project of Science and Technology,No.21ZXGWSY00040;and the Tianjin Health Research Project,No.TJWJ2022QN043.

摘　　要：BACKGROUND Sterol O-acyltransferase 1(SOAT1)is an important target in the diagnosis and treatment of liver cancer.However,the prognostic value of SOAT1 in patients with hepatocellular carcinoma(HCC)is still not clear.AIM To investigate the correlation of SOAT1 expression with HCC,using RNA-seq and gene expression data of The Cancer Genome Atlas(TCGA)-liver hepatocellular carcinoma(LIHC)and pan-cancer.METHODS The correlation between SOAT1 expression and HCC was analyzed.Cox hazard regression models were conducted to investigate the prognostic value of SOAT1 in HCC.Overall survival and disease-specific survival were explored based on TCGA-LIHC data.Biological processes and functional pathways mediated by SOAT1 were characterized by gene ontology(GO)analysis and the Kyoto Encyclopedia of Genes and Genomes(KEGG)analysis of differentially expressed genes.In addition,the protein-protein interaction network and co-expression analyses of SOAT1 in HCC were performed to better understand the regulatory mechanisms of SOAT1 in this malignancy.RESULTS SOAT1 and SOAT2 were highly expressed in unpaired samples,while only SOAT1 was highly expressed in paired samples.The area under the receiver operating characteristic curve of SOAT1 expression in tumor samples from LIHC patients compared with para-carcinoma tissues was 0.748,while the area under the curve of SOAT1 expression in tumor samples from LIHC patients compared with GTEx was 0.676.Patients with higher SOAT1 expression had lower survival rates.Results from GO/KEGG and gene set enrichment analyses suggested that the PI3K/AKT signaling pathway,the IL-18 signaling pathway,the calcium signaling pathway,secreted factors,the Wnt signaling pathway,the Jak/STAT signaling pathway,the MAPK family signaling pathway,and cell–cell communication were involved in such association.SOAT1 expression was positively associated with the abundance of macrophages,Th2 cells,T helper cells,CD56bright natural killer cells,and Th1 cells,and negatively linked to the abundance of Th17 cells,dendrit

关 键 词：Sterol O-acyltransferase 1 Hepatocellular carcinoma PROGNOSTIC IMMUNE 

分 类 号：R735.7[医药卫生—肿瘤]