线粒体转录因子A在肿瘤细胞中的作用  

Role of Mitochondrial Transcription Factor A in Cancer Cells

作　　者：于洋[1] 郭文文[2] 

机构地区：[1]南京医科大学第二附属医院,江苏南京210009 [2]南京医科大学第二附属医院临床分子基因检测中心,江苏南京210011

出　　处：《中国肿瘤》2016年第1期58-62,共5页China Cancer

基　　金：南京医科大学科技发展基金重点项目(2013NJMU051)

摘　　要：线粒体转录因子A(mitochondrial transcription factor A,TFAM或m TFA)是由核基因编码的高迁移率族类蛋白因子,定位于线粒体内。TFAM是影响线粒体DNA(mt DNA)复制和转录的重要调节因子。近年来许多研究已表明,TFAM基因表达水平与多种肿瘤相关。全文介绍了近年来国内外关于TFAM与多种类型肿瘤的发生、发展及预后关系的研究进展。提示TFAM可作为潜在的生物标志物用于预测肿瘤的发生及预后,也可以作为肿瘤治疗的可能靶点,为肿瘤治疗提供新的思路。Human mitochondrial transcription factor A（TFAM,also known as m TFA）,a high-mobility group（HMG） protein,is encoded by the nuclear gene and imported into mitochondria. It plays an essential role in the transcription and replication of mitochondrial DNA（mt DNA）. Numerous stud-ies have shown that the expression of TFAM gene is associated with many human cancers. In this review,we summarize the recent research progress in the relationship between TFAM and several major human cancers. It shows that TFAM plays an important role in the occurance,development and prognosis of cancers. It indicated that TFAM may be used as a candidate biomarker for the occurance and prognosis of cancers and therapeutic target for cancer therapy,which helps to provide new ideas and means for seeking the possible therapeutic target for cancers.

关 键 词：线粒体转录因子A 线粒体DNA 肿瘤 

分 类 号：R730.1[医药卫生—肿瘤] R730.2[医药卫生—临床医学]