鼻咽癌调强放疗中再程计划保护腮腺对口干燥症影响的临床研究  

A Study of Replanning Radiation Mode During Intensity Modulated Radiation Therapy to Reduce Parotid Gland Injury in Nasopharyngeal Carcinoma

作　　者：郑勤红[1] 邹燕[1] 廖小方[1] 魏启春[2] 郑晓珍[1] 胡伟[1] 彭政[1] 余文亮[1] 

机构地区：[1]衢州市人民医院,浙江衢州324000 [2]浙江大学附属第二医院,浙江杭州310009

出　　处：《肿瘤学杂志》2016年第1期39-44,共6页Journal of Chinese Oncology

基　　金：衢州市科技局项目(201268)

摘　　要：[目的]研究鼻咽癌调强放疗中再程计划改野对减轻腮腺损伤,降低口干燥症发生率的影响。[方法]入组117例拟行调强放疗的鼻咽癌患者,分单次计划放疗组(46例)和再程计划放疗组(71例)。对两组靶区受照射剂量和体积、双侧腮腺受照射剂量和体积、4年局部控制率和4年生存率进行比较。[结果]两组靶区受照射剂量及体积变化差异无统计学意义(P>0.05),但再程计划放疗组双侧腮腺受照射剂量和体积均较单次计划放疗组显著降低(P<0.05)。再程计划放疗组口干燥症严重程度较单次计划放疗组低(P=0.015)。再程计划放疗组和单次计划放疗组的4年局部控制率分别为94.4%和82.6%(P=0.046),4年总生存率分别为84.5%和80.4%(P=0.573)。[结论]鼻咽癌调强放疗中再程计划改野模式可减轻腮腺损伤,降低口干燥症的发生。[Purpose]To investigate the influence of replanning radiation mode during intensity modulated radiation therapy（IMRT） in nasopharyngeal carcinoma on relieving parotid gland injury and reducing the incidence of xerostomia. [ Methods ] One hundred and seventeen cases with na- sopharyngeal carcinoma which were intended to receive definitive radiotherapy were divided into simple planning radiation group and replanning radiation group. Gross tumor volume （GTV） dose and volume,parotid gland dose and volume,4-year local control rate,4-year survival in two groups were analyzed. [ Results ] There was a significant difference in parotid gland damage, while no difference was observed in GTV doses and volume between two groups （P〈0.05）. The 4-years local control rate was 94.4% and 82.6% （P=0.046） in replanning radiation group and simple planning radiation group, and the 4-year overall survival was 84.5% and 80.4%（P=0.573） respec- tively. Xerostomia happening in replanning radiation group were lower than that of control group （P=0.015）. [Conclusion] Replanning radiation mode during IMRT may reduce the incidence of parotid gland injury and xerostomia in nasopharyngeal carcinoma patients.

关 键 词：鼻咽肿瘤 再程计划 口干燥症 调强放疗 

分 类 号：R739.62[医药卫生—肿瘤]