Foxp3调节的CD_4^+CD_(25)^+Treg细胞计数与肺腺癌患者分期之间的关系  

Relationship between CD_4^+CD_(25)^+Treg cells regulated by Foxp3 and stages of lung adenocarcinoma patients

作　　者：保鹏涛[1] 魏星 赵卫国[1] 冯金栋[1] 刘宇[1] 李芸[1] 汤丽萍[1] 

机构地区：[1]中国人民解放军第309医院呼吸科,北京100091 [2]总参卫生技术培训中心,北京100091

出　　处：《临床肺科杂志》2016年第3期525-527,共3页Journal of Clinical Pulmonary Medicine

基　　金：中国人民解放军第309医院院内课题(No 2014MS-008)

摘　　要：目的分析Foxp3调节的CD_C^+CD_(25)^+Treg细胞计数与肺腺癌患者分期之间的关系。方法流式细胞法检测临床各期肺腺癌患者和健康人群血清中表达Foxp3的CD_4^+CD_(25)^+Treg细胞计数,并观察化疗及手术对肺腺癌患者血清中Foxp3水平的影响。结果肺腺癌各期患者血清中CD_4^+CD_(25)^+Treg细胞计数均明显高于健康人群,而且同样与肿瘤分期呈正相关,经手术或化疗干预后患者外周血清中该细胞计数下降明显(P<0.05)。结论 Foxp3调控的CD_4^+CD_(25)^+Treg细胞在肺腺癌的发生发展中可能起着重要的作用,对其深入研究将有助于肺腺癌的早期诊断,并为肺腺癌治疗提供新的靶点。Objective To analyze the relationship between CD4^＋ CD25^＋ Treg cells regulated by Foxp3 and the stages of lung adenocarcinoma patients. Methods CD4^＋ CD25^＋ Treg cells was counted by Flow cytometry method in lung adenocarcinoma patients at different stages and healthy controls, and the effect of chemotherapy and surgery on Foxp3 in serum was observed. Results CD4^＋ CD25^＋ Treg cells were significantly higher in lung adenocarcinoma patients than in healthy people, and they were positively correlated with tumor stages. In addition, the cell counts in patients decreased significantly after surgery or chemotherapy （ P 〈 0.05 ）. Conclusion CD4^＋ CD25^＋ Treg cells regulated by Foxp3 may play an important role in lung adenocarcinoma, which will be helpful for the early diagnosis and as a new therapeutic target of lung adenocarcinoma.

关 键 词：FOXP3 腺癌 分期 

分 类 号：R734.2[医药卫生—肿瘤]