血浆同型半胱氨酸水平与老年痴呆的关系及叶酸、维生素B_(12)的干预效果研究  

Study on relationship between plasma Hcy level and senile dementia and interventional effects of folic acid and vitamin

作　　者：李梁蜜[1] 方芳[1] 曹文英[1] 李承[1] 

机构地区：[1]重庆市第九人民医院神经内科,重庆400700

出　　处：《实用临床医药杂志》2016年第1期42-44,共3页Journal of Clinical Medicine in Practice

基　　金：中国高校医学期刊临床专项资金(11523076)

摘　　要：目的探讨血浆同型半胱氨酸(Hcy)水平与老年痴呆的关系及叶酸和维生素的干预效果。方法选取老年痴呆患者130例(痴呆组)和同期健康体检老年人45例(对照组),采用高效液相色谱法测定血浆Hcy浓度,对高Hcy血症痴呆患者进行叶酸和维生素干预治疗,检测干预3周后患者血液Hcy、叶酸和维生素B_(12)水平。结果痴呆组Hcy浓度高于对照组,叶酸、维生素B_(12)浓度低于对照组(P<0.05或P<0.01);不同痴呆类型患者Hcy浓度均高于对照组(P<0.05),叶酸和维生素B_(12)低于对照组(P<0.05);高Hcy血症痴呆患者叶酸和维生素干预治疗后,Hcy水平显著降低,叶酸和维生素B_(12)水平显著升高(P<0.01)。结论高水平Hcy可能是老年人痴呆发生的危险因素,叶酸和维生素干预治疗可有效降低患者体内Hcy水平。Objective To explore the relationship between plasma homocysteine（ Hcy） level and senile dementia and the interventional effects of folic acid and vitamin. Methods A total of 130 patients with senile dementia and another 45 healthy people undergoing physical examination at the same period were selected as dementia group and control group,respectively. High-performance liquid chromatography（ HPLC） was applied to detect plasma Hcy level. Folic acid and vitamin was given to dementia group,after which plasma Hcy,folic acid and vitamin B（12） levels were detected 3 weeks after interventions. Results Dementia group was evidently higher in Hcy level but apparently lower in folic acid and vitamin B（12） levels than control group（ P〈0.05 or P〈0.01）. And patients with different-type dementia were prominently higher in Hcy level（ P〈0.05）,but apparently lower in folic acid and vitamin B（12） levels than control group（ P〈0.05）. After treated with folic acid and vitamin,patients with high homocystinemia had significantly decreased Hcy level and markedly increased folic acid and vitamin B（12） levels. Conclusion High level of Hcy may be a risk factor for patients with senile dementia,which can be effectively reduced by interventions with folic acid and vitamin.

关 键 词：同型半胱氨酸 叶酸 维生素 老年痴呆症 

分 类 号：R742[医药卫生—神经病学与精神病学]