局部晚期鼻咽癌调强放疗联合同期化疗的比较  

A Comparative Study of Intensity- Modulated Radiotherapy with Concurrent FP or TP Chemotherapy in Patients with Locally Advanced Nasopharyngeal Carcinoma

作　　者：尹宏[1,2] 何志刚[1,2] 向舫[1,2] 李煜[1,2] 罗英[1,2] 

机构地区：[1]湖南省肿瘤医院,湖南长沙410013 [2]中南大学湘雅医学院附属肿瘤医院,湖南长沙410013

出　　处：《现代临床医学》2016年第1期41-43,共3页Journal of Modern Clinical Medicine

摘　　要：目的:比较局部晚期鼻咽癌行调强放疗(IMRT)同期FP、TP方案化疗的差异。方法:将我院2010年5月至2012年10月收治的120例Ⅲ期、Ⅳa期局部晚期鼻咽癌患者分为2组,观察组行IMRT同期FP化疗,对照组行IMRT同期TP化疗。比较2组的疗效和不良反应。结果:随访率100%,观察组1年生存率为100.00%,2年生存率为95.0%;对照组1年生存率为100.00%,2年生存率为91.7%,2组比较无显著性差异(P>0.05)。≥3级白细胞减少、血小板减少发生率观察组分别为28.3%和15.0%,对照组分别为65.0%和23.3%,2组比较有显著性差异(P<0.05)。结论:2组生存率无明显差异,但IMRT同期TP化疗的不良反应较高。Objective： To investigate the differents in patients with locally advanced nasopharyngeal carcinoma who received intensity- modulated radiotherapy（ IMRT） with two kind of chemotherapies. Methods： A retrospective analysis was performed on the clinical data of 120 patients with stage Ⅲ or Ⅳa nasopharyngeal carcinoma who were admitted to our hospital from May 2010 to October 2012. 60 received IMRT with 5- fluorouracil plus nedaplatin（ FP） chemotherapy,and 60 received IMRT with taxol plus nedaplatin（ TP） chemotherapy. The Kaplan- Meier method wasused to calculate the survival rates,and the log- rank test was used to analyze the survival difference; the chisquare test was used to compare the acute toxicities in the two groups. Results：The follow- up rate was 100. 00%. The 1、2- yearssurvival rate in the IMRT / FP group were 100. 00% and 95. 0% respectively,versus 100% and 91. 7% in the IMRT / TP group. No significant difference was found between the two groups（ P 〉0. 05）. The incidence rates of leukopenia（ grade ≥ 3）,thrombocytopenia（ grade ≥ 3） in the IMRT / FP group were 28. 3% and 15. 0%respectively,versus 65. 0% and 23. 3% in the IMRT / TP group（ P 〈0. 05）. Conclusion： Compares with IMRT with concurrent FP chemotherapy,IMRT with concurrent TP chemotherapy does not lead to significantly better in survival rate,but have more acute toxicities.

关 键 词：鼻咽癌 调强放疗 同期放化疗 预后 毒副反应 

分 类 号：R739.63[医药卫生—肿瘤]