吡柔比星和吉西他滨交替灌注预防高危非肌层浸润性膀胱癌TURBt术后复发的临床观察  

THE CLINICAL EFFECTS OF ALTERNATIVE INSTILLATION OF PIRARUBICIN AND GEMCITABINE TO ASSIST THE TREATMENT OF HI GH-RISK NMIBC AFTER TURBT

作　　者：田建海 吕建 周鲁莲 徐岩 李绘 郭怀远 孙利国 

机构地区：[1]临沂市肿瘤医院,山东临沂276002

出　　处：《山东医学高等专科学校学报》2016年第1期9-12,共4页Journal of Shandong Medical College

基　　金：临沂市科技发展计划项目(No.201313056)

摘　　要：目的探讨吡柔比星(THP)、吉西他滨(GEM)交替膀胱灌注辅助经尿道膀胱肿瘤切除术(TURBt)治疗高危非肌层浸润性膀胱癌的临床效果。方法高危非肌层浸润性膀胱癌患者154例,均行TURBt术。术后分别行吡柔比星(THP组,60例)、吉西他滨(GEM组,43例)和GEM/THP交替(交替组,51例)膀胱灌注治疗,观察三组膀胱癌复发率、进展率和不良反应发生情况。结果全部病例随访2年,交替灌注组膀胱癌复发率低于THP组和GEM组(P值均0.05),各组进展率及不良反应发生率无明显差异(P值均>0.05)。结论 THP、GEM交替膀胱灌注辅助手术治疗高危非肌层浸润性膀胱癌可降低术后二年内复发率,但不能改变其进展。对其更长期的有效性评估,尚需进一步研究。Objective To observe the clinical effects of the alternative instillation of pirarubicin and gemcitabine to assist the treatment of high-risk non-muscle invasive bladder cancer（NMIBC）after transurethral resection of bladder tumor（TURBT）.Methods 154 cases of high-risk NMIBC were underwent TURBT.After operations,pirarubicin was used in 60 cases,gemcitabine was used in 43 cases and the alternative bladder instillation of pirarubicin and gemcitabine was in 51 cases.The recurrence rates,progression rates and adverse reactions in the three groups were observed.Results The two-year follow-up surveys showed that the recurrence rate of bladder cancer was significantly lower in the group treated with the alternative instillation of pirarubicin and gemcitabine than in the groups treated with only pirarubicinor gemcitabine（p〈0.05）,but there existed no significant difference in the progress rates and adverse reactions between the three groups（P 〉0.05）.Conclusion The alternative instillation of pirarubicin and gemcitabine can be used to assist the treatment of high-risk NMIBC after TURBT in two years,but its long-term effectiveness needs further research.

关 键 词：膀胱肿瘤 癌 吉西他滨 吡柔比星 交替灌注 

分 类 号：R737.14[医药卫生—肿瘤]