磁性附着体中软磁合金引起小鼠成纤维细胞L929凋亡的研究  

Induction of Apoptosis by Magnetic Attachment in the Mouse Fibroblast L929 Cells

作　　者：于学垠[1] 

机构地区：[1]沈阳市第七人民医院口腔科,辽宁沈阳110003

出　　处：《中国医药指南》2016年第4期30-31,共2页Guide of China Medicine

摘　　要：目的研究磁性附着体中软磁合金对小鼠成纤维细胞L929凋亡的影响,进而评价其生物相容性。方法提取含钛合金、软磁合金、钴铬合金的浸提液,分别以25%、50%、100%浓度处理L929细胞24 h,并测量细胞凋亡率(AP)。结果随着金属浸提液浓度的增加,L929细胞凋亡率亦增加,软磁合金与含钛合金及钴铬合金之间AP值的差异均无统计学意义(P>0.05)。结论本实验为磁性附着体的临床应用提供一定的生物学依据。磁性附着体中软磁合金的生物相容性要求合临床应用材料的要求,可以在临床推广。Objective To evaluate the biocompatibility of stainless steel which will be used in the new magnetic attachment by apoptosis assay for the mouse fibroblast L929 cells. Methods The cells are cultured in extracting liquids of different experimental materials which concentration is 25%, 50%, 100% for 24 hours, then determine the apoptotic rate of the cells. Results The apoptotic rate of the same material raise along with the improvement of the density. There is no difference among the materials（P〈0.05）. Conclusion The soft magnetic stainless steel meets the requirement for clinical application.

关 键 词：生物相容性 磁性附着体 凋亡 

分 类 号：R783[医药卫生—口腔医学]