评价喹硫平治疗中国精神分裂症患者急性期兴奋激越的疗效和安全性  

Evaluation of Efficacy and Safety of Quetiapine Treating Excitement and Agitation in Chinese Schizophrenia Patients During Acute Phase

作　　者：王丹[1] 

机构地区：[1]河南省新乡市新乡医学院第二附属医院,河南新乡453002

出　　处：《中国医药指南》2016年第4期65-66,共2页Guide of China Medicine

摘　　要：目的探讨喹硫平治疗中国精神分裂症患者急性期兴奋激越的临床疗效及安全性。方法选取100例急性期兴奋激越精神分裂症患者随机分为观察组与对照组,每组50例。对照组给予药物氟哌啶醇治疗,观察组给予药物喹硫平治疗,均连续用药8周。结果观察组患者治疗总有效率(90%)明显高于对照组(68%)(P<0.05);而观察组患者不良反应发生率(4%)明显低对照组(60%)(P<0.05)。结论喹硫平治疗中国精神分裂症患者急性期兴奋激越临床效果显著,优于氟哌啶醇治疗。Objective To discuss the clinical efficacy and safety of quetiapine treating excitement and agitation in Chinese schizophrenia patients during acute phase. Methods 100 cases of acute phase schizophrenia with excitement and agitation were selected and randomly divided into observation group and control group, 50 patients in each group. Control group was treated with the drug haloperidol, observation group was treated with the drug quetiapine. Two groups used continuous medication for 8 weeks. Results The total effective rate of observation group（90%） was higher than that of control group（68%）（P〈0.05）; the incidence of adverse reactions of observation group（4%） was lower than that of control group（60%）（P〈0.05）. Conclusion Quetiapine treating excitement and agitation in Chinese schizophrenia patients during acute phase has a significant clinical effect, which is better than haloperidol.

关 键 词：喹硫平 神经分裂症 急性期兴奋激越 疗效 安全性 

分 类 号：R749.3[医药卫生—神经病学与精神病学]