氟达拉滨联合环磷酰胺对慢性淋巴细胞白血病的临床疗效研究  

Clinical effect of fludarabine combined with cyclophosphamide on chronic lymphocytic leukemia

作　　者：袁海龙[1] 古力巴旦木.艾则孜 曹海洲[1] 陈刚[1] 曲建华[1] 

机构地区：[1]新疆医科大学第一附属医院血液病中心一病区,乌鲁木齐830054

出　　处：《中国临床药理学杂志》2016年第4期306-308,共3页The Chinese Journal of Clinical Pharmacology

基　　金：新疆维吾尔自治区自然科学基金资助项目(2013211A100)

摘　　要：目的观察氟达拉滨联合环磷酰胺对慢性淋巴细胞白血病的临床疗效及对外周血Th17和Treg细胞比例的影响。方法 200例慢性淋巴细胞白血病患者随机分为对照组100例和试验组100例。对照组患者第1~3天静脉滴注氟达拉滨25 mg·m^(-2);试验组第1~3天静脉滴注氟达拉滨25 mg·m^(-2)和环磷酰胺250 mg·m^(-2)。2组均4周为1个周期,治疗2个周期。比较2组患者的临床疗效、不良反应发生情况以及外周血Th17和Treg细胞比例。结果试验组患者总改善率为98.0%,显著高于对照组的72.0%(P<0.05)。试验组患者总不良反应发生率为8.0%,显著低于对照组的29.0%(P<0.05)。试验组患者Th17细胞和Treg细胞状况均显著优于对照组(P<0.05)。结论氟达拉滨联合环磷酰胺能够有效地治疗慢性淋巴细胞白血病,降低不良反应发生率,并能显著改善外周血Th17和Treg细胞比例。Objective To evaluated the clinical efficacy of fludarabine combined with cyclophosphamide on chronic lymphocytic leukemia and the effect on peripheral blood Th17 and Treg cell ratio. Methods Two hundred patients were randomly divided into control group（ n = 100） and treatment group（ n = 100）. Patients in control group intravenously given fludarabine 25 mg · m^（-2）on 1- 3 d; patients in treatment group were intravenously given fludarabine 25 mg·m^（-2）and cyclophosphamide 250mg· m^（-2）on 1- 3 d. A cycle of both groups were 4 weeks,and all treated for 2 cycles. The clinical efficacy,incidence of adverse drug reactions,and the ratio of Th17 and Treg cells in peripheral blood were observed. Results The total improvement rate of treatment group was98. 0%, higher than that in control group, which was 72. 0%（ P〈0. 05）. The incidence of adverse drug reactions in treatment group was 8. 0%, significantly lower than 29. 0% in control group（ P〈0. 05）. The Th17 cells and Treg cells in treatment group were significantly better than those in control group（ P〈0. 05）.Conclusion Fludarabine combined with cyclophosphamide had a good clinical efficiency on chronic lymphocytic leukemia,which reduced the risk of adverse reactions and can significantly improve the Th17 and Treg cells in peripheral blood.

关 键 词：氟达拉滨 环磷酰胺 慢性淋巴细胞白血病 TH17 TREG细胞 

分 类 号：R733.7[医药卫生—肿瘤] R973[医药卫生—临床医学]