叶酸在培美曲塞化疗方案中作用的研究进展  

Research progress of the effect of folic acid in pemetrexed-based chemotherapy

作　　者：张文静[1] 夏阳[1] 白冲[1] 王卓[1] 

机构地区：[1]第二军医大学长海医院药学部,上海200433

出　　处：《肿瘤研究与临床》2016年第1期61-63,共3页Cancer Research and Clinic

摘　　要：文章对补充不同叶酸剂量的培美曲塞方案疗效和安全性进行分析，重点关注高剂量叶酸补充对培美曲塞疗效和毒性影响，探讨培美曲塞初始治疗方案中叶酸首次给药时间，以及同型半胱氨酸水平能否作为一个理想的生物指标预测培美曲塞相关血液性毒性。This review analyzed the effect of folic acid on pemetrexed efficacy and toxicity, especially high-does folic acid supplementation. The optimal duration for supplementation prior to the first dose of pemetrexed has not been defined. The review also explored whether total plasma homocysteine levels can be as a marker to predict and avoid toxicity from pemetrexed therapy.

关 键 词：培美曲塞 叶酸 同型半胱氨酸 剂量 

分 类 号：R730.5[医药卫生—肿瘤]