Claudins在乳腺癌中的研究进展  

Research Progress of Claudins in Breast Cancer

作　　者：钱松颖 李建一[1] 张文海[1] 

机构地区：[1]中国医科大学附属盛京医院乳腺外科,辽宁沈阳110004

出　　处：《中国普外基础与临床杂志》2016年第2期248-252,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的了解Claudins家族成员对乳腺癌细胞增殖、活化影响机制的研究进展。方法检索近年来国内外有关Claudins在乳腺癌中研究进展的相关文献并对其进行综述。结果 Claudins在哺乳动物中有24个Claudin成员,在人类中Claudin-13缺失。Claudins的表达与分布模式具有高度的组织特异性,且在许多组织中表达多重Claudin蛋白。Claudin蛋白的表达可从转录水平进行调控、转录因子及合成后修饰协同调控、受后转录水平调控。Claudins家族与上皮-间质转化有关。目前研究较多较明确的主要有Claudin-1、-2、-4、-6及其他一些亚型,Claudin-1的表达可预示肿瘤的不良预后,Claudin-2与乳腺癌肝转移的关系密切,Claudin-4与三阴性乳腺癌密切相关,Claudin-6在乳腺癌形成中的作用尚有争议。除上述Claudins外,还有其他Claudins成员在乳腺健康组织及乳腺恶性肿瘤中起一定作用,Claudin-5有可能通过N-WASP和ROCK信号通路参与乳腺癌的转移,CD24和Claudin-7免疫抑制对乳腺浸润性导管癌预后有指导意义,Claudin-16和HAPLN3基因在人类乳腺癌中表达显著提高,Claudin-20导致乳腺癌细胞成为侵袭性较强的亚型且可减少上皮转化的抵抗。目前国际上提出了三阴性乳腺癌中Claudin-low亚型的概念,其在众多方面与其他亚型乳腺癌均有所不同,较三阴性乳腺癌中的其他亚型预后良好。结论 Claudin家族作为紧密连接蛋白的重要组成成员,已被证实与上皮-间质转化有关,认为Claudin家族在乳腺癌细胞的解离、活化、侵袭及转移方面起重要作用,但是究竟是哪些Claudin成员在乳腺癌侵袭、转移中起主要作用尚未有明确定论,除此之外,关于某些Claudin成员在乳腺癌中的作用目前也有相悖的研究,其原因有可能是某些Claudin成员在不同乳腺癌亚型中的作用不同或截然相反,所以未来仍需细化Claudin成员在不同乳腺癌亚型中的作用。Objective To understand research progress of influence of claudins on proliferation and activation for breast cancer. Method The relevant literatures of influence of claudins on proliferation and activation for breast cancer were retrieved and reviewed. Results The claudins had 24 members in mammals, claudin-13 was missing in human beings. Expression and distribution mode of the claudins possessed highly tissue-specific, and multiple proteins were expressed in many organizations. The expressions of claudins could be regulated from the levels of transcription and post-transcription, coordinately regulated by the transcription factor and post-synthetic modifications. Claudins were related to epithelial-mesenchymal transition. Now the studies were relatively clear those focused on claudin-1,-2,-4,-6, and other subtypes, and the expression of claudin-1 indicated the poor prognosis of tumor; claudin-2 was closely related to liver metastasis of breast cancer; claudin-4 was closely related to triple negative breast cancer; the function of claudin-6 in the breast cancer was controversial. In addition to the claudins mentioned above, other claudin members also played certain roles in normal breast and malignant breast tumors. Claudin-5 might participate in metastasis of breast cancer through NWASP and ROCK signal pathway; CD-24 and claudin-7 immunodepression had a certain guiding significance on prognosis of invasive ductal carcinoma; the expressions of claudin-16 and HAPLN3 gene were remarkably increased in human breast cancer; Claudin-20 induced breast cancer cells into a subtype that possessed the high invasiveness and weakened the resistance of epithelial-mesenchymal transition. Recently, the claudin-low subtype was proposed, and it differed from other types of breast cancer in many aspects, and also it had a better prognosis than other types of triple negative breast cancer. Conclusions Claudin, being an important member of tight junction protein, is confirmed to be related to epithelialmesenchymal transition. Claudi

关 键 词：乳腺癌 Claudin蛋白 紧密连接蛋白 上皮-间质转化 

分 类 号：R737.9[医药卫生—肿瘤]