基于宣威地区“开放式火塘”的实验装置研究  

Research and Design of an Experimental Apparatus Based on the “Open Fireplace” in Xuanwei District

作　　者：杨加鹏[1] 黄云超[1] 资文华 白云宝[3] 李光剑[1] 叶联华[1] 周永春[1] 赵光强[1] 雷玉洁[1] 陈小波[1] 陈颖[1] 张艳军[1] 

机构地区：[1]昆明医科大学第三附属医院/云南省肿瘤医院胸外一科,云南省肺癌研究重点实验室,昆明650118 [2]云南瑞升科技(烟草)有限公司,昆明650000 [3]云南省环境科学研究院,昆明650000

出　　处：《生物医学工程学杂志》2016年第1期101-107,共7页Journal of Biomedical Engineering

基　　金：国家自然科学基金重点支持资助项目(U1202224)

摘　　要：云南宣威地区是中国乃至世界肺癌的高发区,研究表明当地肺癌高发与当地燃煤方式致室内空气污染密切相关。本研究针对宣威地区"开放式火塘"致室内空气污染这一现状,设计开发了室内空气污染模拟系统,并建立了宣威地区煤烟尘致F344大鼠肺部损伤的模型。该模型基于室内空气污染模拟系统,实现了信号多路控制和多路采集功能,并采用进程控制符(PID)算法对实验中各测试点进行了多项式拟合,模拟出了可吸入细颗粒物(PM2.5)相对恒定的空气污染状态。结果表明,该系统能够按照要求模拟出各种不同的空气污染状态,可为室内空气污染对人体损伤的评价提供新的试验方法,为研究宣威地区肺癌的发生提供了新思路。Xuanwei district in Yunnan Province of China has pretty high incidence of lung cancer in China,even around the world.Studies have shown that there exists a close relationship between lung cancer and local indoor air pollution caused by Bituminous coal.Considering that the indoor air pollution in Xuanwei District is caused by＂open fireplace＂,an indoor air pollution simulation system was designed,and an F344 rats lung damage model was established for this indoor air pollution fireplace.The model is based on indoor air pollution simulation system with signal multiplexer control and multi-channel acquisition,and mining PID algorithm was used for polynomial fitting to each test point,and a relatively constant PM2.5air pollution status was simulated.The results showed that the system could simulate a variety of states of air pollution,provide a new test method for evaluation of human injury caused by indoor air pollution and a new idea for the study of the incidence of lung cancer in Xuanwei district and other places.

关 键 词：宣威 空气污染 实验装置 肺损伤 

分 类 号：R734.2[医药卫生—肿瘤] R122[医药卫生—临床医学]