不同年龄保乳治疗的乳腺癌患者临床病理特征及预后分析  

Analysis of clinicopathological features and prognosis in different-age patients with breast cancer treated with breast-conserving therapy

作　　者：穆兰[1] 肖盟[1] 刘伟色 刘苗[1] 王欣[1] 

机构地区：[1]天津医科大学肿瘤医院乳腺肿瘤一科,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,乳腺癌防治教育部重点实验室,300060

出　　处：《天津医药》2016年第2期205-209,共5页Tianjin Medical Journal

基　　金：国家自然科学基金资助项目(81472472)

摘　　要：目的 分析不同年龄保乳治疗的乳腺癌患者临床病理特征及预后。方法 回顾性分析1997年10月—2010年5月天津医科大学肿瘤医院收治的827例行保乳治疗的乳腺癌患者的临床资料,根据诊断乳腺癌时年龄不同分3组,比较3组患者临床病理特征及生存情况。结果 827例患者中,≤35岁组129例、36~54岁组530例、≥55岁组168例。≤35岁组患者中淋巴结转移数≥4的患者比例较大,且激素受体阴性率也较高。≤35岁组、36~54岁组、≥55岁组5年无局部复发生存率分别为86.0%、93.6%、94.0%（P〈0.01）,5年无远处转移生存率分别为88.4%、91.3%、94.6%（P〉0.05）,5年总生存率分别为91.5%、94.3%、95.2%（P〉0.05）。多因素分析显示,年龄≤35岁组的患者5年局部复发风险较36~54岁组及≥55岁组患者显著增高,5年远处转移风险高于≥55岁组的患者（P〈0.05）,但5年死亡风险并未增加（P〉0.05）。结论 ≤35岁乳腺癌患者保乳术后5年局部复发及远处转移风险较高,5年死亡风险并未增加,仍可接受保乳治疗。Objective To analyze the clinicopathological features and prognosis in patients with breast cancer treated with breast-conserving therapy according to the age when breast cancer diagnosed. Methods Clinical data of 827 patients with breast-conserving therapy in Tianjin Medical University Cancer Institute and Hospital from October 1997 to May 2010 were analyzed retrospectively. According to age when breast cancer was diagnosed, patients were subdivided into three groups. Clinicopathological characteristics and survival were compared between three groups. Results Of the 827 patients, 129 cases were 435 years old, 530 cases were 36-54 years old and 168 cases were aged 〉155 years. The proportion of lymph node metastasis number ≥4 and the negative rate of hormone receptors were higher in patients with age ≤35 years old. The 5-year local regional recurrence-free survival rates were 86.0%, 93.6%, and 94.0% for patients aged ≤35 years old, 36-54 years old, and ≥55 years old, respectively （P 〈 0.01）. The 5-year distant metastasis-free survival rates were 88.4%, 91.3%, and 94.6% for patients with age ≤35 years old, 36-54 years old, and 〉155 years old, respectively （P 〉 0.05）. The 5-year overall survival rates were 91.5%, 94.3%, and 95.2% for patients aged ≤35 years old, 36-54 years old, and≥55 years old, respec- tively （P 〉 0.05）. Multivariate analysis showed that 5-year local regional relapse risks were significantly increased in patients aged ≤35 years compared to patients aged 36-54 years and ≥55 years （P 〈 0.05）, and the 5-year distant metastasis risk was higher in this group than that of patients aged ≥55 years （P = 0.014）, while 5-year mortality risk was not increased in patients with age ≤35 years old （P 〉 0.05）. Conclusion After breast-conserving therapy, the risk of 5-year local regional recurrence and distant metastasis are relatively higher in patients aged ≤35 years old, while the risk of mortality within 5 years does not increase in this group. Patie

关 键 词：乳腺肿瘤 年龄组 肿瘤复发 局部 肿瘤转移 死亡 保乳治疗 

分 类 号：R737.9[医药卫生—肿瘤]