复发性抑郁障碍认知功能与营养不良性短杆菌素结合蛋白1基因多态性的关联研究  

Correlation of cognitive function and dystrobrevin binding protein 1 gene polymorphisms in patients with recurrent depressive disorder

作　　者：刘发荣 陈彬彬 廖震华 张振清 季建林[2] 

机构地区：[1]厦门市仙岳医院心理科,厦门361012 [2]复旦大学附属中山医院心理科,上海200032

出　　处：《中华行为医学与脑科学杂志》2016年第1期44-49,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：厦门市科技局科技计划项目（3502Z20124024）

摘　　要：目的 探讨营养不良性短杆菌素结合蛋白1（DTNBP1）基因多态性与复发性抑郁障碍患者认知功能的关系.方法 采用病例对照研究,选取复发性抑郁障碍患者49名和与之性别、年龄、受教育程度匹配的健康对照60名.采用汉密尔顿抑郁量表（HAMD）评定患者的临床症状,使用韦氏成人记忆测验、威斯康星卡片分类测验（WCST）、连线测验（TMT）、词语流畅性测验（VFT）、Stroop色词测验评定两组人群的认知功能,应用PCR-RFLP方法对DTNBP1基因的两个位点进行分型,数据采用SPSS 16.0进行统计学分析.结果 所用样本的基因分布均符合Hardy-Weinberg平衡（P＞0.05）;连线测验-A的时间、韦氏成人记忆的数字广度、视觉再生、联想学习和顺数,威斯康星卡片分类测验的分类数、完成总数和错误应答数、Stroop色词测验的字义干扰反应时结果在患者组中分别为（73.4±30.5）分、（9.6±2.3）分、（9.6±2.3）分、（9.7±2.2）分、（9.1±2.4）分、（1.8±1.6）分、（47.6±1.1）分、（28.5±5.3）分、（18.4±9.0）分,健康对照组分别为（56.2±11.7）分、（8.1±3.0）分、（7.4±3.1）分、（6.1±4.2）分、（7.2±2.9）分、（2.5±1.8）分、（47.3±0.7）分、（24.1±9.3）分、（25.3±9.5）分,均差异具有统计学意义（P＜0.05）.rs9476867位点GG基因型对连线测验的干扰数明显高于CC和CG基因型;rs16876738位点AG基因型对连线测验-A的时间明显高于AA型和GG型,这两个基因型对复发性抑郁障碍患者的注意能力有影响.结论 DTNBP1基因多态性与复发性抑郁障碍患者的认知功能相关.Objective To investigate the relationship between dystrobrevin binding protein 1 （DTNBP1） gene polymorphisms and cognitive function in patients with recurrent depressive disorder.Methods 49 recurrent depressive disorder patients and 60 age-,gender-and education-matched normal controls were recruited in this case-control study.Clinical symptoms were evaluated by HAMD and Wechsler adult memory scale,Wisconsin card sorting test,trail making test（TMT）,verbal fluency test （VFT）,S troop colorword test were used to evaluate cognitive function.The gene polymorphisms of DTNBP1 were determined by PCR-RFLP technique.SPSS 16.0 was used for statistical analysis.Results The distributions of genotypes in the patients and controls were consistent with Hardy-Weinberg equilibrium（P＞0.05）.The time in trail making A task （73.4±30.5 vs 56.2± 11.7）,the digital Span （9.6±2.3 vs 8.1±3.0）,visual reproduction （9.6±2.3 vs 7.4±3.1）,paired association learning （9.7±2.2 vs 6.1±4.2） and Spilling forward （9.1 ±2.4 vs 7.2±2.9） in Wechsler adult memory scale,the categories completed （1.8 ± 1.6 vs 2.5 ± 1.8）,total trials （47.6± 1.1 vs 47.3± 0.7） and error numbers （28.5±5.3 vs 24.1±9.3） in WCST performs,and the word meaning interference score （18.4±9.0 vs 25.3±9.5） in Stroop color-word test were monitored.Patients with the genotype of rs9476867 G/G got higher interference number than patients with DTNBP1 rs9476867 C/G and C/C,and patients with the genotype of rs16876738 A/G spent more time to finish TMT-A than patients with rs16876738 G/G and A/A.G/G single nucleotide polymorphism （SNP） of rs9476867 and A/G SNP of rs16876738 affected attention ability.Conclusion DTNBP 1 gene polymorphisms are correlated with cognitive function in recurrent depressive disorder patients.

关 键 词：复发性抑郁障碍 认知 营养不良性短杆菌素结合蛋白1 基因多态性 

分 类 号：R749.4[医药卫生—神经病学与精神病学]