Exploiting kinase polypharmacology for nerve regeneration  

作　　者：Hassan Al-Ali John L.Bixby Vance P.Lemmon 

机构地区：[1]Miami Project to Cure Paralysis, University of Miami [2]Center for Computational Science, University of Miami [3]Department of Neurological Surgery, University of Miami [4]Department of Molecular & Cellular Pharmacology, University of Miami

出　　处：《Neural Regeneration Research》2016年第1期71-72,共2页中国神经再生研究（英文版）

摘　　要：The human central nervous system（CNS）has a markedly poor capacity for regenerating its axons following injury.This appears to be due to two main causes：1）a developmentally regulated decline in regenerative capacity within mature CNS neurons,and 2）the presence of biological components that constitute barriers to axon regeneration（e.g.,growth-inhibitory molecules）.The human central nervous system（CNS）has a markedly poor capacity for regenerating its axons following injury.This appears to be due to two main causes：1）a developmentally regulated decline in regenerative capacity within mature CNS neurons,and 2）the presence of biological components that constitute barriers to axon regeneration（e.g.,growth-inhibitory molecules）.

关 键 词：regeneration alterations mature markedly constitute regenerative barriers phenotypic similarity inhibit 

分 类 号：R741[医药卫生—神经病学与精神病学]