VASP在结肠癌组织中的表达及其对预后的影响  

Expression of VASP in colonic carcinoma and its relation to prognosis

作　　者：宋胜江[1] 孙利敏[2] 徐定银[1] 陈震[1] 

机构地区：[1]瑞安市人民医院普外科,浙江瑞安325200 [2]瑞安市人民医院病理科,浙江瑞安325200

出　　处：《实用肿瘤杂志》2016年第1期48-52,共5页Journal of Practical Oncology

基　　金：温州市2014年公益性科技项目(Y20140555)

摘　　要：目的探讨血管扩张刺激磷蛋白（vasodilator stimulated phosphoprotein,VASP）在结肠癌中的表达及对预后的影响。方法收集手术切除的60例结肠癌组织及对应癌旁组织,采用免疫组织化学法检测VASP蛋白的表达情况。随访3年,采用χ2检验分析VASP蛋白与临床病理资料间的相关性,Kaplan-Meier生存曲线分析VASP蛋白表达对患者预后的影响。结果 VASP在结肠癌组织中表达水平高于对应癌旁组织（P〈0.05）。结肠癌组织中VASP蛋白阳性表达与肿瘤直径增大（≥5 cm）、淋巴结转移及高TNM分期（Ⅲ~Ⅳ期）呈正相关（均P〈0.05）。VASP蛋白阳性表达的患者3年总生存率及无瘤生存率均低于VASP蛋白表达阴性患者（均P〈0.05）。Cox多因素回归分析证实,VASP阳性表达是结肠癌患者不良预后的独立危险因素之一（P〈0.05）。结论 VASP在结肠癌组织中表达上调,高水平VASP蛋白表达与肿瘤恶性临床病理特征及不良预后有关,VASP可能成为结肠癌患者诊断和预后评价的有效分子标志物。Objective To investigate the expression of vasodilator stimulated phosphoprotein（ VASP） in colonic carcinoma and its relation to prognosis. Methods The expression of VASP in colonic carcinoma and pericancerous tissues was detected by immunohistochemistry in 60 colonic carcinoma patients. The relationship between VASP expression and clinicopathological features was analyzed by χ2test. Kaplan-Meier survival curve was used to measure prognosis. Results The expression of VASP was significantly higher in colonic carcinoma tissues than in pericancerous tissues（ P〈0. 05）.High VASP expression was positively correlated with large tumor size（ ≥5 cm）,lymphatic metastasis and advanced TNM stage（ Ⅲ ~ Ⅳ）（ all P〈0. 05）. The 3-year overall survival rate and the disease-free survival rate were lower in patients with positive VASP expression than in those with negative VASP expression（ both P〈0. 05）. Conclusion VASP expression is up-regulated in colonic carcinoma and the elevated VASP level is associated with malignant clinicopathological features and poor prognosis,which indicates that VASP may be used as a prognostic marker for patients with colonic carcinoma.

关 键 词：结肠肿瘤/病理学 磷蛋白类/代谢 淋巴转移 基因表达 预后 免疫组织化学 

分 类 号：R735.35[医药卫生—肿瘤] R730.23[医药卫生—临床医学]