超选择性动脉栓塞化疗治疗耳鼻喉肿瘤82例  

Super-selective arterial embolism chemotherapy for 82 patients with otorhinolaryngological cancer

作　　者：白尚杰[1] 

机构地区：[1]延边大学附属医院耳鼻咽喉科,吉林延边133000

出　　处：《实用肿瘤杂志》2016年第1期75-78,共4页Journal of Practical Oncology

摘　　要：目的评价耳鼻喉肿瘤患者经超选择性动脉栓塞化疗后的临床疗效。方法收集82例经病理组织学确诊的耳鼻喉肿瘤晚期患者,均接受超选择性动脉栓塞术并化疗药物灌注治疗（1~2次）,经病情评估,条件允许则接受进一步的治疗（手术或放疗）。随访≥1年,观察总有效率、不良反应以及无进展生存时间和总生存率。结果80例（97.6%）患者接受1次超选择性动脉栓塞并化疗灌注治疗,2.4%患者接受2次。治疗后3月总有效率为87.8%。围术期所有患者无严重并发症。其中,47.6%患者有骨髓抑制（Ⅰ级）,39.0%出现轻度消化道不良反应,11.0%有低热,持续1-3天后自行消退。随访第1年末,2例死亡;其余健在,部分为带瘤生存。结论超选择性动脉栓塞并灌注化疗药物有助于提高晚期耳鼻喉肿瘤的近期疗效和1年生存率。Objective To evaluate the clinical effect of super-selective arterial embolism chemotherapy（ SSAEC）for patients with otorhinolaryngological（ ENT） cancer. Methods Eighty-two patients with advanced ENT cancer diagnosed by histopathology underwent SSAEC. All patients were followed up for ≥1 year. The total effective rate,adverse effects,the progression-free survival time and overall survival rate were analyzed. Results Eighty patients（ 97. 6%） received one SSAEC treatment and only 2 patients（ 2. 4%） received 2 treatments. The total effective rate was 87. 8% 3months after treatments. No serious complications were observed for all patients during the perioperative period. 47. 6% of the patients had grade I bone marrow suppression,39. 0% had mild gastrointestinal side effects,and 11. 0% had low-grade fever which was dissipated 1-3 days later. At the end of the first year follow up,there were 2 fatal cases and the rest survived. Conclusion Super-selective arterial embolism chemotherapy can improve short-term efficacy and 1-year survival rate for patients with advanced ENT cancer.

关 键 词：耳鼻咽喉肿瘤/治疗 栓塞 治疗性 药物疗法 综合疗法 

分 类 号：R739.6[医药卫生—肿瘤] R730.5[医药卫生—临床医学]