小肠勾画方式对胰腺癌放疗计划剂量评估的影响  

Effects of small bowel contouring techniques on radiotherapy dose assessment of pancreatic cancer

作　　者：李婷婷[1] 张建英[1] 吴莉莉[1] 

机构地区：[1]复旦大学附属中山医院放疗科,上海200032

出　　处：《实用肿瘤杂志》2016年第1期79-82,共4页Journal of Practical Oncology

摘　　要：目的在晚期胰腺癌放疗计划评估中,比较2种勾画方式对小肠剂量体积限值的影响。方法对30例晚期胰腺癌患者,采用Small Bowel和Peritoneal Space方式分别勾画小肠,利用剂量体积直方图对小肠受到同一剂量照射体积(V5~V50)进行分析,同时将小肠受照体积为2 cm^3、1 cm^3、0.1 cm^3的剂量作为最大剂量DMAX(D_(MAX2),D_(MAX1),D_(MAX0.1))进行对比分析。结果 Small Bowel和Peritoneal Space方式勾画的小肠接受同一剂量照射体积(V5~V50)及最大剂量D_(MAX2)、DMAX1、D_(MAX0.1)比较差异均有统计学意义(均P<0.05)。2种勾画方式小肠V5~V50均具有相关性(均P<0.05),而最大剂量D_(MAX2)、DMAX1、D_(MAX0.1)无相关性(均P>0.05)。结论 Small Bowel和Peritoneal Space勾画方式对小肠的剂量体积和最大剂量有差异,对晚期胰腺癌放疗计划评估时,2种勾画方式需要给予小肠不同的剂量体积限值。Objective To compare the effects of two small bowel contouring techniques on dose volume limits during radiotherapy assessment for advanced pancreatic cancer. Methods Small bowel（ SB） and peritoneal space（ PS） methods were applied to contour the small bowel in 30 patients with advanced pancreatic cancer. Dose-volume histogram（ DVH）data were extracted and analyzed against the small bowel receiving the same dose volumes（ V5-V50）,while the maximum doses（ DMAX2,DMAX1,DMAX0. 1） of the small bowel irradiation volumes（ 2 cm3,1 cm3,0. 1 cm3） were compared between two techniques. Results SB method and PS method were significantly different in the same dose volumes（ V5-V50） received by small bowel and the maximum doses（ DMAX2,DMAX1,DMAX0. 1）（ all P〈0. 05）. The V5-V50 of both contouring methods were correlated with each other（ all P〈0. 05）,yet the correlation of the maximum doses（ DMAX2,DMAX1,DMAX0. 1） showed no significant difference（ all P〉0. 05）. Conclusions There are significant differences in volumes and maximum doses of small bowel contoured by small bowel and peritoneal space methods. During the radiotherapy assessment for advanced pancreatic cancer,different dose volume limits of the small bowel need to be determined by two contouring techniques.

关 键 词：胰腺肿瘤/放射疗法 立体定位技术 小肠/辐射效应 放射治疗剂量 治疗结果 

分 类 号：R735.9[医药卫生—肿瘤] R730.55[医药卫生—临床医学]