老年人腔隙性脑梗死与血浆Klotho蛋白水平的相关性  

Association between plasma Klotho protein level and lacunar cerebral infarction in the elderly

作　　者：裴文楠[1] 李宝善[1] 钟淼[1] 唐渝平[1] 蒋宜[1] 李婷婷[1] 

机构地区：[1]重庆市急救医疗中心老年科,400014

出　　处：《中华老年医学杂志》2016年第2期168-170,共3页Chinese Journal of Geriatrics

基　　金：重庆市卫生与计划生育委员会科研计划项目（2013-2-104,2014-2-079）

摘　　要：目的探讨血浆Klotho蛋白水平与老年人腔隙性脑梗死的相关性。方法选择年龄大于60岁腔隙性脑梗死患者88例作为研究组，另选择年龄、男女比例一致、无腔隙性脑梗死老年人90例作为对照组。应用酶联免疫吸附法（ELISA）检测血浆Klotho蛋白水平，并与对照组进行比较，统计分析血浆Klotho水平与老年腔隙性脑梗死的相关性。结果腔隙性脑梗死患者组血浆Klotho蛋白水平（689．4±40．8）ng／L明显低于对照组（848．5±38．7）ng／L（P=0．009），高血压患者比例（83．0％）明显高于对照组（66．7％，P=0．04），年龄、性别比例、体质指数、血脂异常、糖尿病、冠心病患者在两组间差异无统计学意义。多因素Logistic回归分析显示，低血浆Klotho蛋白水平和高血压是老年人腔隙性脑梗死的独立危险因素（0R值分别为3．325、2．413，P值分别为0．003、0．021）。结论低血浆Klotho蛋白水平与腔隙性脑梗死发病有关，监测血浆Klotho蛋白水平对腔隙性脑梗死的预防、诊断及预后判断有重要临床意义。Objective To investigate the association between plasma Klotho protein level and lacunar cerebral infarction in the elderly. Methods Eighty eight patients with lacunar cerebral infarction aged over 60 years were selected as the observation group, and 90 age- and gender- matched elderly patients without lacunar infarction as the control group. The protein level of Klotho was tested by enzyme-linked immunosorbent assay （ELISA）. Klotho protein level was compared between the observation and control groups. The correlation between plasma Klotho level and lacunar infarction in elderly patients was analyzed. Results Compared with the control group, lacunar infarction group showed that Klotho protein level was decreased （（689.4~40.8） ng/L v.~ （848.5~38.7） ng/L, P= 0. 009], and the proportion of patients with hypertension was increased （83.0% vs 66.7%, P= 0.04）. There was no significant difference in age, gender, body mass index （BMI）, dyslipidemia, diabetes mellitus and coronary heart disease between the two groups. The multivariate logistic regression analysis showed that the low plasma level of Klotho protein and hypertension were identified as the independent risk factors for Lacunar infarction （OR=3. 325 and 2. 413, P=0. 003 and 0. 0217 respectively）. Conclusions Klotho protein level may be associated with lacunar cerebral infarction in elderly people. Monitoring plasma Klotho protein level has an important clinical significance in the prevention, diagnosis and prognosis of lacunar cerebral infarction.

关 键 词：KLOTHO蛋白 脑梗死 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]