丹参酮ⅡA磺酸钠联合依达拉奉对脑梗死局部脑血流及血液流变学影响  

Effects of Sodium Tanshinone IIA Sulfonate Combined with Edaravone on Focal Cerebral Infarction Blood Flow and Blood Rheology

作　　者：李龙珠[1] 刘家军[1] 张梅[1] 郭俐宏[2] 

机构地区：[1]湖北省十堰市中医医院,湖北十堰442012 [2]湖北省十堰市太和医院,湖北十堰442000

出　　处：《辽宁中医药大学学报》2016年第2期182-184,共3页Journal of Liaoning University of Traditional Chinese Medicine

摘　　要：目的:观察丹参酮ⅡA磺酸钠注射液联合依达拉奉治疗脑梗死的临床疗效并分析其作用机制。方法:收集我院于2014年1月—2015年2月住院的脑梗死患者246例,采用随机数字表随机分为对照组、联合治疗组。对照组按常规治疗方法,口服巴米尔1次0.5 g/(次·d)、静脉滴注依达拉奉注射液;联合治疗组口服巴咪尔,静脉滴注丹参酮ⅡA磺酸钠注射液+依达拉奉注射液;采用TCD脑血流仪动态观测两组治疗前(入院当天)、第4天、第7天、第21天局部脑血流(RCBF),记录血小板集聚率、纤维蛋白原、全血低切黏度、全血高切黏度、红细胞压积等5项血液流变学指标,并计算神经功能缺损评分(ESS)分值及治愈率。结果:联合治疗组脑梗死患者于第5天RCBF即逐步恢复,血液流变学各指标均明显降低,ESS分值及治愈率明显提高,与本组治疗前及对照组比较,差异均有统计学意义,P<0.05。结论:丹参酮ⅡA磺酸钠与依达拉奉两药联合应用治疗脑梗死具有明显的药物协同作用,可增加患者RCBF、促进患者神经功能恢复、改善患者血液流变学指标并提高治愈率。Objective：To observe the clinical therapeutic effect of tanshinone II A sodium sulfonate injection combined with edaravone in treatment of cerebral infarction and the analysis of its mechanism. Methods：Collected in our hospital in 2014 January—2015 February hospitalized patients with cerebral infarction in 246 cases,were randomly divided into control group,combined treatment group. The control group with conventional treatment,oral aspirin bamyl 0.5 g/day,intravenous infusion of Edaravone Injection;combined treatment group oral bamil,intravenous infusion of sodium tanshinone A sulfonate injection ＋ edaravone injection;using TCD brain blood flowmeter dynamic observation of the two groups before treatment（day of admission）,4,7,21 regional cerebral blood flow（RCBF）,recorded platelet aggregation rate,fibrinogen,whole blood low shear viscosity,index of whole blood high shear viscosity,hematocrit five items of blood rheology,and calculate the neural function defect score（ESS）scores and the cure rate. Results：The combined treatment group in patients with cerebral infarction in the 5 d RCBF is gradually restored,the index of hemorheology were significantly decreased,ESS score and improve the cure rate,and the group before treatment and the control group,the difference was statistically significant,P0.05. Conclusion：Tanshinone II A sodium sulfonate and edaravone combination of two drugs in the treatment of cerebral infarction has obvious synergistic drug,can be increased in the patients with RCBF,and promote the recovery of neurological function in patients with,improving hemorheology and improve the cure rate.

关 键 词：丹参酮ⅡA磺酸钠 依达拉奉 药物协同作用 脑梗死 局部脑血流 血液流变学 

分 类 号：R743[医药卫生—神经病学与精神病学]